• # LGM Pharma is a Ixabepilone CAS# 219989-84-1 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
  • # Questions? Call our customer API support number 1-(800)-881-8210.
  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
  • Inquire about this product >>

Product Details:

  • Product Name: Ixabepilone
  • CAS #: 219989-84-1
  • Mode of Action:

    Binding of Ixabepilone to beta-tubulins (e.g. beta-III tubulin) stabilizes microtubules. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing. Like taxol, Ixabepilone binds to the αβ-tubulin heterodimer subunit. Once bound, the rate of αβ-tubulin dissociation decreases, thus stabilizing the microtubules.

  • IUPAC: (1R, 5S, 6S, 7R, 10S, 14S, 16S)-6, 10-dihydroxy-1, 5, 7, 9, 9-pentamethyl-14-[(E)-1-(2-methyl-1, 3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14.1.0]heptadecane-8, 12-dione
  • ATC: L01DC04
  • PubChem: 6445540
  • Formula: C27H42N2O5
  • Molecular Mass: 506.698
  • Synonyms: Aza-epothilone B, Azaepothilone B, BMS-247550
  • SMILES: C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@H](NC(=O)C[C@@H](O)C(C)(C)C(=O)[C@@H](C)[C@H]1O)C(C)=CC1=CSC(C)=N1
  • InChl: InChIKey=FABUFPQFXZVHFB-CFWQTKTJSA-N
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants

 

  • Technical packages as well as access to filed DMF,
    ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any
    submission type based on specific customer requirements