Product Name

Ibritumomab Tiuxetan

CAS Number

206181-63-7

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Product Name:
Ibritumomab Tiuxetan
CAS Number:
206181-63-7
Indication:
For treatment of non-Hodgkin’s lymphoma
Mode of Action:

The Fab segment of the antibody targets the CD20 epitope on B-cells, allowing the radioactive yttrium to destroy the cell via production of beta particles.

Pharmacodynamics:

Ibritumomab is a murine monoclonal antibody against CD20 that has been radiolabeled with yttrium-90.

Metabolism:

Most likely removed by opsonization via the reticuloendothelial system when bound to B cells, or by human antimurine antibody production

IUPAC:
Immunoglobulin G1, anti-(human CD20 (antigen)) (mouse monoclonal IDEC-Y2B8 gamma1-chain), disulfide with mouse monoclonal IDEC-Y2B8 kappa-chain, dimer, N-(2-(bis(carboxymethyl)amino)-3-(4-isothiocyanatophenyl)propyl)-N-(2-(bis(carboxymethyl)amino)propyl)glycine conjugate
DrugBank:
DB00078
Molecular Mass:
570.5968
Synonyms:
BAY 86-5128, BAY86-5128, Ibritumomab, Ibritumomab tiuxetan, IDEC-129, IDEC-Y2B8, Immunoglobulin G1 (mouse monoclonal IDEC-Y2B8 gamma1-chain anti-human antigen CD20), disulfide with mouse monoclonal IDEC-Y2B8 K-chain, dimer, N-(2-(bis(carboxymethyl)amino)-3-(p-isothiocyanatophenyl)propyl)-N-(2-(bis(carboxymethyl)amino)propyl)glycine conjugate. Molecular weight is approximately 1500 daltons, SHL 749, UNII-4Q52C550XK, Zevalin

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Questions? Call our customer API support number 1-(800)-881-8210. 

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