Product Name

Ibritumomab Tiuxetan

Name: Ibritumomab Tiuxetan - LGM Pharma
SKU: 206181-63-7

CAS Number

206181-63-7

LGM Pharma is an API distributor. LGM Pharma supplies APIs as per CGMP with DMF support, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, or pharmacies.

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Product Name:

Ibritumomab Tiuxetan

CAS Number:

206181-63-7

Indication:

For treatment of non-Hodgkin’s lymphoma

Mode of Action:

The Fab segment of the antibody targets the CD20 epitope on B-cells, allowing the radioactive yttrium to destroy the cell via production of beta particles.

Pharmacodynamics:

Ibritumomab is a murine monoclonal antibody against CD20 that has been radiolabeled with yttrium-90.

Metabolism:

Most likely removed by opsonization via the reticuloendothelial system when bound to B cells, or by human antimurine antibody production

IUPAC:

Immunoglobulin G1, anti-(human CD20 (antigen)) (mouse monoclonal IDEC-Y2B8 gamma1-chain), disulfide with mouse monoclonal IDEC-Y2B8 kappa-chain, dimer, N-(2-(bis(carboxymethyl)amino)-3-(4-isothiocyanatophenyl)propyl)-N-(2-(bis(carboxymethyl)amino)propyl)glycine conjugate

DrugBank:

DB00078

Molecular Mass:

570.5968

Synonyms:

BAY 86-5128, BAY86-5128, Ibritumomab, Ibritumomab tiuxetan, IDEC-129, IDEC-Y2B8, Immunoglobulin G1 (mouse monoclonal IDEC-Y2B8 gamma1-chain anti-human antigen CD20), disulfide with mouse monoclonal IDEC-Y2B8 K-chain, dimer, N-(2-(bis(carboxymethyl)amino)-3-(p-isothiocyanatophenyl)propyl)-N-(2-(bis(carboxymethyl)amino)propyl)glycine conjugate. Molecular weight is approximately 1500 daltons, SHL 749, UNII-4Q52C550XK, Zevalin

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210.

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Ibritumomab Tiuxetan

206181-63-7

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