Product Name

Ibritumomab Tiuxetan

CAS Number

206181-63-7

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Product Name:

Ibritumomab Tiuxetan

CAS Number:

206181-63-7

Indication:

For treatment of non-Hodgkin’s lymphoma

Mode of Action:

The Fab segment of the antibody targets the CD20 epitope on B-cells, allowing the radioactive yttrium to destroy the cell via production of beta particles.

Pharmacodynamics:

Ibritumomab is a murine monoclonal antibody against CD20 that has been radiolabeled with yttrium-90.

Metabolism:

Most likely removed by opsonization via the reticuloendothelial system when bound to B cells, or by human antimurine antibody production

IUPAC:

Immunoglobulin G1, anti-(human CD20 (antigen)) (mouse monoclonal IDEC-Y2B8 gamma1-chain), disulfide with mouse monoclonal IDEC-Y2B8 kappa-chain, dimer, N-(2-(bis(carboxymethyl)amino)-3-(4-isothiocyanatophenyl)propyl)-N-(2-(bis(carboxymethyl)amino)propyl)glycine conjugate

DrugBank:

DB00078

Molecular Mass:

570.5968

Synonyms:

BAY 86-5128, BAY86-5128, Ibritumomab, Ibritumomab tiuxetan, IDEC-129, IDEC-Y2B8, Immunoglobulin G1 (mouse monoclonal IDEC-Y2B8 gamma1-chain anti-human antigen CD20), disulfide with mouse monoclonal IDEC-Y2B8 K-chain, dimer, N-(2-(bis(carboxymethyl)amino)-3-(p-isothiocyanatophenyl)propyl)-N-(2-(bis(carboxymethyl)amino)propyl)glycine conjugate. Molecular weight is approximately 1500 daltons, SHL 749, UNII-4Q52C550XK, Zevalin

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LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

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Ibritumomab Tiuxetan

206181-63-7

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