Product Name

Goserelin Acetate

CAS Number

145781-92-6

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Product Name:
Goserelin Acetate
CAS Number:
145781-92-6
Indication:
Used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty.
Mode of Action:

Goserelin is a synthetic decapeptide analogue of LHRH. Goserelin acts as a potent inhibitor of pituitary gonadotropin secretion when administered in the biodegradable formulation. The result is sustained suppression of LH and serum testosterone levels.

Pharmacodynamics:

The pharmacokinetics of goserelin have been determined in both male and female healthy volunteers and patients. In these studies, goserelin was administered as a single 250µg (aqueous solution) dose and as a single or multiple 3.6 mg depot dose by subcutaneous route.

Metabolism:

Hepatic

Toxicity:

No experience of overdosage from clinical trials.

IUPAC:
1-9-Luteinizing hormone-releasing factor (swine), 6-(O-(1, 1-dimethylethyl)-D-serine)-, 2-(aminocarbonyl)hydrazide, acetate (salt)
ATC:
L02AE03
PubChem:
5311128
DrugBank:
BTD00113
Formula:
C59-H84-N18-O14.x-C2-H4-O2
Molecular Mass:
1329.4762
SMILES:
CC(C)C[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NNC(=O)N)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3c[nH]c4c3cccc4)NC(=O)[C@H](Cc5c[nH]cn5)NC(=O)[C@@H]6CCC(=O)N6.CC(=O)O
AHFS Code:
68:18.00, 92:00.00

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