Product Name

Fosfomycin Tromethamine

CAS Number

78964-85-9

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Product Name:
Fosfomycin Tromethamine
CAS Number:
78964-85-9
IUPAC:
[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]azanium;hydroxy-[(2R,3S)-3-methyloxiran-2-yl]phosphinate
PubChem:
54331
Formula:
C7H18NO7P
Molecular Mass:
259.19 g/mol
Synonyms:
Fosfomycin, Fosfomycin Trometamol Salt, fosfomycin tromethamine, Monuril, Phosphomycin, Phosphonomycin, Tromethamine, Fosfomycin
SMILES:
CC1C(O1)P(=O)(O)[O-].C(C(CO)(CO)[NH3+])O
InChi:
InChI=1S/C4H11NO3.C3H7O4P/c5-4(1-6,2-7)3-8;1-2-3(7-2)8(4,5)6/h6-8H,1-3,5H2;2-3H,1H3,(H2,4,5,6)/t;2-,3+/m.0/s1
Product Description:

Fosfomycin trometamol (fosfomycin tromethamine) is approved in numerous countries worldwide, mainly for the treatment of uncomplicated urinary tract infections (UTIs). Fosfomycin has good in vitro activity against common uropathogens, such as Escherichia coli (including extended-spectrum β-lactamase-producing E. coli), Proteus mirabilis, Klebsiella pneumoniae and Staphylococcus saprophyticus, and the susceptibility of uropathogens to fosfomycin has remained relatively stable over time. A single oral dose of fosfomycin trometamol 3 g (the approved dosage) achieves high concentrations in urine.

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