Product Name

Flutamide

CAS Number

13311-84-7

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Product Name:
Flutamide
CAS Number:
13311-84-7
Indication:
For the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate
Mode of Action:

Flutamide is a nonsteroidal antiandrogen that blocks the action of both endogenous and exogenous testosterone by binding to the androgen receptor. In addition Flutamide is a potent inhibitor of testosterone-stimulated prostatic DNA synthesis. Moreover, it is capable of inhibiting prostatic nuclear uptake of androgen.

Pharmacodynamics:

Flutamide is a nonsteroidal antiandrogen. In animal studies, flutamide demonstrates potent antiandrogenic effects. It exerts its antiandrogenic action by inhibiting androgen uptake and/or by inhibiting nuclear binding of androgen in target tissues or both. Prostatic carcinoma is known to be androgen-sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen, e.g. castration. Elevations of plasma testosterone and estradiol levels have been noted following flutamide administration.

Metabolism:

Flutamide is rapidly and extensively metabolized, with flutamide comprising only 2.5% of plasma radioactivity 1 hour after administration.

Toxicity:

In animal studies with flutamide alone, signs of overdose included hypoactivity, piloerection, slow respiration, ataxia, and/or lacrimation, anorexia, tranquilization, emesis, and methemoglobinemia.

IUPAC:
2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
ATC:
L02BB01
PubChem:
3397
DrugBank:
DB00499 (APRD00984)
Formula:
C32H47F5O3S
Molecular Mass:
276.2118
Synonyms:
Flutamide USP25
SMILES:
CC(C)C(=O)NC1=CC(=C(C=C1)[N+]([O-])=O)C(F)(F)F
AHFS Code:
10:00.0
InChi:
MKXKFYHWDHIYRV-UHFFFAOYSA-N
General Reference:
General Reference:

  1. Link

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