Placeholder

Fluconazole

  • # LGM Pharma is a Fluconazole CAS# 86386-73-4 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
  • # Questions? Call our customer API support number 1-(800)-881-8210.
  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
  • Inquire about this product >>

Product Details:

  • Product Name: Fluconazole
  • CAS #: 86386-73-4
  • Mode of Action:

    Fluconazole interacts with 14-_ demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

  • Pharmacodynamics:

    Fluconazole, a synthetic antifungal agent of the imidazole class, is used to treat vaginal candidiasis. It inhibits the fungal lanosterol 14 alpha-demethylase which thereby prevents the formation of ergosterol which is an essential component in the fungal cell membrane.

  • Metabolism:

    Hepatic

  • Toxicity:

    Symptoms of overdose include hallucinations and paranoid behavior.

  • IUPAC: 2-(2, 4-difluorophenyl)-1, 3-bis(1H-1, 2, 4-triazol-1-yl)propan-2-ol
  • ATC: D01AC15 J02AC01
  • PubChem: 3365
  • DrugBank: DB00196 (APRD00327)
  • Formula: C26H32F2O7
  • Molecular Mass: 306.2708
  • SMILES: OC(CN1C=NC=N1)(CN1C=NC=N1)C1=C(F)C=C(F)C=C1
  • AHFS Code: 08:14.1
  • InChl: RFHAOTPXVQNOHP-UHFFFAOYSA-N
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants

 

  • Technical packages as well as access to filed DMF,
    ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any
    submission type based on specific customer requirements