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Fidaxomicin

  • # LGM Pharma is a Fidaxomicin CAS# 873857-62-6 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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Product Details:

  • Product Name: Fidaxomicin
  • CAS #: 873857-62-6
  • Mode of Action:

    Fidaxomicin is a bactericidal-type antibiotic that inhibits RNA polymerase sigma subunit. RNA polymerase is responsible for transcription in the bacteria therefore fidaxomicin will inhibit protein synthesis. As a result, apoptosis is triggered in susceptible organisms such as C. difficile.

  • Pharmacodynamics:

    The minimum inhibitory concentration for 90% of organisms for fidaxomicin against C. difficile is 0.9978 to 2 µg/mL.

  • Metabolism:

    Fidaxomicin is hydrolyzed by gastric acid or intestinal microsomes into a less active metabolite (OP-1118). The cytochrome enzyme system are not involved in the metabolism of fidaxomicin.

  • ATC: A07AA12
  • Formula: C52-H74-Cl2-O18
  • Molecular Mass: 1058.0446
  • Synonyms: BRN 5228707, Clostomicin B1, Dificid, Fidaxomicin, Lipiarmicin, Lipiarmycin, Lipiarmycin A 3, OPT 80, OPT-80, PAR 01, PAR 101, PAR-101, R-Tiacumicin B, Tiacumicin B, UNII-Z5N076G8YQ
  • SMILES: CC[C@H]1C=C(C)[C@@H](O)CC=CC=C(CO[C@@H]2O[C@H](C)[C@@H](OC(=O)C3=C(CC)C(Cl)=C(O)C(Cl)=C3O)[C@H](O)[C@@H]2OC)C(=O)OC(CC=C(/C)C=C(C)[C@@H]1O[C@@H]1OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]1O)[C@@H](C)O
  • AHFS Code: 8:12.12.92
  • General Reference:

     

    1. Artsimovitch I, Seddon J, Sears P: Fidaxomicin is an inhibitor of the initiation of bacterial RNA synthesis. Clin Infect Dis. 2012 Aug;55 Suppl 2:S127-31. doi: 10.1093/cid/cis358. Pubmed
    2. Crawford T, Huesgen E, Danziger L: Fidaxomicin: a novel macrocyclic antibiotic for the treatment of Clostridium difficile infection. Am J Health Syst Pharm. 2012 Jun 1;69(11):933-43. doi: 10.2146/ajhp110371. Pubmed

     

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