Product Name

Fidaxomicin

Name: Fidaxomicin - LGM Pharma
SKU: 873857-62-6

CAS Number

873857-62-6

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Product Name:

Fidaxomicin

CAS Number:

873857-62-6

Indication:

Treatment of Clostridium difficile-associated diarrhea

Mode of Action:

Fidaxomicin is a bactericidal-type antibiotic that inhibits RNA polymerase sigma subunit. RNA polymerase is responsible for transcription in the bacteria therefore fidaxomicin will inhibit protein synthesis. As a result, apoptosis is triggered in susceptible organisms such as C. difficile.

Pharmacodynamics:

The minimum inhibitory concentration for 90% of organisms for fidaxomicin against C. difficile is 0.9978 to 2 µg/mL.

Metabolism:

Fidaxomicin is hydrolyzed by gastric acid or intestinal microsomes into a less active metabolite (OP-1118). The cytochrome enzyme system are not involved in the metabolism of fidaxomicin.

ATC:

A07AA12

Formula:

C52-H74-Cl2-O18

Molecular Mass:

1058.0446

Synonyms:

BRN 5228707, Clostomicin B1, Dificid, Fidaxomicin, Lipiarmicin, Lipiarmycin, Lipiarmycin A 3, OPT 80, OPT-80, PAR 01, PAR 101, PAR-101, R-Tiacumicin B, Tiacumicin B, UNII-Z5N076G8YQ

SMILES:

CC[C@H]1C=C(C)[C@@H](O)CC=CC=C(CO[C@@H]2O[C@H](C)[C@@H](OC(=O)C3=C(CC)C(Cl)=C(O)C(Cl)=C3O)[C@H](O)[C@@H]2OC)C(=O)OC(CC=C(/C)C=C(C)[C@@H]1O[C@@H]1OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]1O)[C@@H](C)O

AHFS Code:

8:12.12.92

General Reference:

Artsimovitch I, Seddon J, Sears P: Fidaxomicin is an inhibitor of the initiation of bacterial RNA synthesis. Clin Infect Dis. 2012 Aug;55 Suppl 2:S127-31. doi: 10.1093/cid/cis358. Pubmed
Crawford T, Huesgen E, Danziger L: Fidaxomicin: a novel macrocyclic antibiotic for the treatment of Clostridium difficile infection. Am J Health Syst Pharm. 2012 Jun 1;69(11):933-43. doi: 10.2146/ajhp110371. Pubmed

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Fidaxomicin

873857-62-6

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