Product Name


CAS Number


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Product Name:
CAS Number:
Treatment of Clostridium difficile-associated diarrhea
Mode of Action:

Fidaxomicin is a bactericidal-type antibiotic that inhibits RNA polymerase sigma subunit. RNA polymerase is responsible for transcription in the bacteria therefore fidaxomicin will inhibit protein synthesis. As a result, apoptosis is triggered in susceptible organisms such as C. difficile.


The minimum inhibitory concentration for 90% of organisms for fidaxomicin against C. difficile is 0.9978 to 2 µg/mL.


Fidaxomicin is hydrolyzed by gastric acid or intestinal microsomes into a less active metabolite (OP-1118). The cytochrome enzyme system are not involved in the metabolism of fidaxomicin.

Molecular Mass:
BRN 5228707, Clostomicin B1, Dificid, Fidaxomicin, Lipiarmicin, Lipiarmycin, Lipiarmycin A 3, OPT 80, OPT-80, PAR 01, PAR 101, PAR-101, R-Tiacumicin B, Tiacumicin B, UNII-Z5N076G8YQ
AHFS Code:
General Reference:
General Reference:


  1. Artsimovitch I, Seddon J, Sears P: Fidaxomicin is an inhibitor of the initiation of bacterial RNA synthesis. Clin Infect Dis. 2012 Aug;55 Suppl 2:S127-31. doi: 10.1093/cid/cis358. Pubmed
  2. Crawford T, Huesgen E, Danziger L: Fidaxomicin: a novel macrocyclic antibiotic for the treatment of Clostridium difficile infection. Am J Health Syst Pharm. 2012 Jun 1;69(11):933-43. doi: 10.2146/ajhp110371. Pubmed


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