Product Name

Fesoterodine

Name: Fesoterodine - LGM Pharma
SKU: 286930-03-8

CAS Number

286930-03-8

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Product Name:

Fesoterodine

CAS Number:

286930-03-8

Indication:

For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).

Mode of Action:

Fesoterodine, once converted to its active metabolite, 5-hydroxymethyltolterodine, acts as a competitive antagonists at muscarinic receptors. This results in the inhibition of bladder contraction, decrease in detrusor pressure, and an incomplete emptying of the bladder.

Pharmacodynamics:

Fesoterodine is a prodrug. In vivo it is broken down into its active metabolite, 5-hydroxymethyl tolterodine, by plasma esterases. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. Therefore, acting as a competitive muscarinic receptor antagonist, fesoterodine ultimately acts to decrease the detrusor pressure by its muscarinic antagonism, thereby decreasing bladder contraction and consequently, the urge to urinate.

IUPAC:

2-[(1R)-3-[bis(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate

ATC:

G04BD11

PubChem:

6918558

DrugBank:

DB06702

Formula:

C₄H₄FN₃O

Molecular Mass:

411.5769

SMILES:

CC(C)N(CC[C@H](C1=CC=CC=C1)C1=C(OC(=O)C(C)C)C=CC(CO)=C1)C(C)C

AHFS Code:

12:08.1

InChi:

DCCSDBARQIPTGU-HSZRJFAPSA-N

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Fesoterodine

286930-03-8

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