Product Name

Famotidine

CAS Number

76824-35-6

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Product Name:
Famotidine
CAS Number:
76824-35-6
Indication:
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Mode of Action:

Famotidine binds competitively to H_-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

Pharmacodynamics:

Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

Metabolism:

Hepatic.

Toxicity:

Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.

IUPAC:
3-[({2-[(diaminomethylidene)amino]-1, 3-thiazol-4-yl}methyl)sulfanyl]-N’-sulfamoylpropanimidamide
ATC:
A02BA03
PubChem:
3325
DrugBank:
DB00927 (APRD00296)
Formula:
C15H17NO2
Molecular Mass:
337.445
Synonyms:
Famotidina [Spanish] Famotidinum [Latin]
SMILES:
NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1
AHFS Code:
56:28.1
InChi:
XUFQPHANEAPEMJ-UHFFFAOYSA-N

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