Product Name

Famciclovir

CAS Number

104227-87-4

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Product Name:
Famciclovir
CAS Number:
104227-87-4
Indication:
For the treatment of acute herpes zoster (shingles). Also for the treatment or suppression of recurrent genital herpes in immunocompetent patients and treatment of recurrent mucocutaneous herpes simplex infections in HIV infected patients.
Mode of Action:

Famciclovir undergoes rapid biotransformation to the active antiviral compound penciclovir, which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). In cells infected with HSV-1, HSV-2 or VZV, viral thymidine kinase phosphorylates penciclovir to a monophosphate form that, in turn, is converted to penciclovir triphosphate by cellular kinases. In vitro studies demonstrate that penciclovir triphosphate inhibits HSV-2 DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited.

Pharmacodynamics:

Famciclovir is a prodrug that undergoes rapid biotransformation to the active antiviral compound penciclovir. Penciclovir is an anti-viral drug which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). Therefore, herpes viral DNA synthesis and replication are selectively inhibited.

Metabolism:

Hepatic

Toxicity:

Symptoms of overdose include constipation, diarrhea, dizziness, fatigue, fever, headache, nausea, and vomiting.

IUPAC:
2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate
ATC:
J05AB09 S01AD07
PubChem:
3324
DrugBank:
DB00426 (APRD00600)
Formula:
C20H32N5O8P
Molecular Mass:
321.3318
Synonyms:
Famciclovirum [INN-Latin] FCV
SMILES:
CC(=O)OCC(CCN1C=NC2=CN=C(N)N=C12)COC(C)=O
AHFS Code:
08:18.3
InChi:
GGXKWVWZWMLJEH-UHFFFAOYSA-N

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Questions? Call our customer API support number 1-(800)-881-8210. 

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