Product Name

Etonogestrel

CAS Number

54048-10-1

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Product Name:
Etonogestrel
CAS Number:
54048-10-1
Indication:
For use as a female contraceptive (depot).
Mode of Action:

Etonogestrel binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like etonogestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

Pharmacodynamics:

Etonogestrel is used as a female contraceptive. Etonogestrel is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Etonogestrel tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.

Metabolism:

Hepatic.

Toxicity:

Symptoms of overdose include nausea, vomiting, vaginal bleeding, and other menstrual irregularities.

IUPAC:
(1S, 2R, 10S, 11S, 14R, 15S)-15-ethyl-14-ethynyl-14-hydroxy-17-methylidenetetracyclo[8.7.0.0, {2, 7}.0, {11, 15}]heptadec-6-en-5-one
ATC:
G03AC08
PubChem:
21729469
DrugBank:
DB00294 (APRD00766)
Formula:
C26H33NO2
Molecular Mass:
324.4565
SMILES:
[H][C@@]12CC[C@@](O)(C#C)[C@@]1(CC)CC(=C)[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H]
InChi:
GCKFUYQCUCGESZ-BPIQYHPVSA-N

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