Product Name

Etanercept

CAS Number

185243-69-0

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Product Name:
Etanercept
CAS Number:
185243-69-0
Indication:
For treatment of severe active rheumatoid arthritis in adults, severe juvenile idiopathic arthritis, ankylosing spondylitis, and severe plaque psoriasis.
Mode of Action:

There are two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75). The biological activity of TNF is dependent upon binding to either cell surface receptor (p75 or p55). Etanercept is a dimeric soluble form of the p75 TNF receptor that can bind to two TNF molecules, thereby effectively removing them from circulation.

Pharmacodynamics:

Tumor necrosis factor TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated levels of TNF are found in tissues and fluids of patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis (AS), and plaque psoriasis. Etanercept binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors.

ATC:
L04AB01
DrugBank:
DB00005 (BIOD00052, BTD00052)
Formula:
C18H19Cl2NO4
Molecular Mass:
51234.9
Synonyms:
CD120b p75 p80 TNF-alpha receptor TNF-R2 Tumor necrosis factor receptor 2 Tumor necrosis factor receptor superfamily member 1B precursor Tumor necrosis factor receptor type II
AHFS Code:
32:00.0

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