Product Name

Ergotamine Tartrate

CAS Number


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Product Name:
Ergotamine Tartrate
CAS Number:
Ergotamine tartrate and caffeine tablets are indicated as a combination therapy to both stop and prevent vascular headaches, migraine headaches and cluster migraines.
Mode of Action:

As part of the ergot alkaloid family, Ergotamine iwas one of the first ergot alkaloids to be isolated. The plentiful vasoconstrictor activities of Ergotamine Tartrate includes positive inhibitory effects on neurogenic inflammation. 


Ergotamine is an alpha adrenergic blocking agent that offers a direct stimulating effect on the blood vessels, thus producing a depression of the central vasomotor centers.


Ergotamine is metabolized in the liver with over 90 percent of the metabolites excreted in the bile as a 2 hour half-life.


Over dosage of Ergotamine Tartrate can be a concern and this has been documented. Symptoms of Ergotism, or an overdose of Ergotamine include vomiting, cyanosis, coma, convulsions and shock. While rare, caution should be taken by patients not to overdose on Ergotamine or products containing this drug. Side effects, albeit mild, reported from patients who took Ergotamine include nausea and dizziness.

C33H35N5O5)2, C4H6O6
Molecular Mass:
(5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione 12'-Hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergotaman-3',6',18-trione
General Reference:
General Reference:
  1. Headache. 2010.
  2. Young, WB. Appropriate use of ergotamine tartrate and dihydroergotamine in the treatment of migraine: current perspectives. Headache. 37 Suppl 1:S42-5, 1997.

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