Product Name

Efalizumab

CAS Number

214745-43-4

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Product Name:
Efalizumab
CAS Number:
214745-43-4
Indication:
For the treatment of adult patients with moderate to severe chronic plaque psoriasis, who are candidates for phototherapy or systemic therapy.
Mode of Action:

Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes. As a result efalizumab decreases cell surface expression of CD11a.

Pharmacodynamics:

Lymphocyte activation and trafficking to skin play a role in the pathophysiology of chronic plaque psoriasis. In psoriatic skin, ICAM-1 cell surface expression is upregulated on endothelium and keratinocytes. Raptiva inhibits the binding of LFA-1 to the intercellular adhesion molecule-1 (ICAM-1), thereby inhibiting the adhesion of leukocytes to other cell types.

IUPAC:
Immunoglobulin G1, anti-(human CD11a (antigen)) (human-mouse monoclonal hu1124 gamma1-chain), disulfide with human-mouse monoclonal hu1124 light chain, dimer
ATC:
L04AA21
DrugBank:
DB00095
Synonyms:
anti-CD11a, Efalizumab, HSDB 7847, Hu 1124, hu1124, Immunoglobulin G 1 (human-mouse monoclonal hu1124 gamma1-chain anti-human antigen CD 11a), disulfide with human-mouse monoclonal hu1124 light chain, dimer. Molecular weight is approximately 146,170 daltons, Raptiva, UNII-XX2MN88N5D, Xanelim
AHFS Code:
84:92.00
General Reference:
General Reference:

 

  1. Pubmed
  2. Descamps V: [Efalizumab] Ann Dermatol Venereol. 2006 Aug-Sep;133(8-9 Pt 1):666-78. Pubmed

 

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Questions? Call our customer API support number 1-(800)-881-8210. 

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