Product Name

Dydrogesterone

CAS Number

152-62-5

LGM Pharma is an API distributor. LGM Pharma can supply CGMP and/or DMF products, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, pharmacies, or any pharmaceutical companies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:
Dydrogesterone
CAS Number:
152-62-5
Indication:
Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions.
Mode of Action:

Dydrogesterone is a progestogen that works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus.

Pharmacodynamics:

Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, dydrogesterone is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Dydrogesterone helps to regulate the healthy growth and normal shedding of the uterus lining. Therefore, it may be useful in the treatment of menstrual disorders such as absent, irregular or painful menstrual periods, infertility, premenstrual syndrome and endometriosis.

Metabolism:

Metabolism is complete to a 20-dihydrodydrogesterone (DHD) metabolite.

Toxicity:

No serious or unexpected toxicity has been observed with dydrogesterone. In acute toxicity studies, the LD50 doses in rats exceeded 4, 640mg/kg for the oral route.

IUPAC:
(1R, 2S, 10S, 11S, 14S, 15S)-14-acetyl-2, 15-dimethyltetracyclo[8.7.0.0, {2, 7}.0, {11, 15}]heptadeca-6, 8-dien-5-one
ATC:
G03DB01
PubChem:
9051
DrugBank:
DB00378 (APRD00941)
Formula:
C2224H3475N621O698S36
Molecular Mass:
312.4458
Synonyms:
10alpha-Isopregnenone Didrogesterone [DCIT] Dydrogesterona [INN-Spanish] Dydrogesteronum [INN-Latin] Hydrogesterone Hydrogestrone Isopregnenone
SMILES:
CC(=O)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@@H]3CC[C@]12C
InChi:
JGMOKGBVKVMRFX-HQZYFCCVSA-N
General Reference:
General Reference:

  1. Link

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210. 

Ask us about this product

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants
  • Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any submission type based on specific customer requirements

Find an API Product

SEARCH
Generic filters