Product Name

Dydrogesterone

Name: Dydrogesterone - LGM Pharma
SKU: 152-62-5

CAS Number

152-62-5

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Product Name:

Dydrogesterone

CAS Number:

152-62-5

Indication:

Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions.

Mode of Action:

Dydrogesterone is a progestogen that works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus.

Pharmacodynamics:

Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, dydrogesterone is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Dydrogesterone helps to regulate the healthy growth and normal shedding of the uterus lining. Therefore, it may be useful in the treatment of menstrual disorders such as absent, irregular or painful menstrual periods, infertility, premenstrual syndrome and endometriosis.

Metabolism:

Metabolism is complete to a 20-dihydrodydrogesterone (DHD) metabolite.

Toxicity:

No serious or unexpected toxicity has been observed with dydrogesterone. In acute toxicity studies, the LD50 doses in rats exceeded 4, 640mg/kg for the oral route.

IUPAC:

(1R, 2S, 10S, 11S, 14S, 15S)-14-acetyl-2, 15-dimethyltetracyclo[8.7.0.0, {2, 7}.0, {11, 15}]heptadeca-6, 8-dien-5-one

ATC:

G03DB01

PubChem:

9051

DrugBank:

DB00378 (APRD00941)

Formula:

C₂₂₂₄H₃₄₇₅N₆₂₁O₆₉₈S₃₆

Molecular Mass:

312.4458

Synonyms:

10alpha-Isopregnenone Didrogesterone [DCIT] Dydrogesterona [INN-Spanish] Dydrogesteronum [INN-Latin] Hydrogesterone Hydrogestrone Isopregnenone

SMILES:

CC(=O)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@@H]3CC[C@]12C

InChi:

JGMOKGBVKVMRFX-HQZYFCCVSA-N

General Reference:

Link

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Dydrogesterone

152-62-5

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