Product Name

Drospirenone

Name: Drospirenone - LGM Pharma
SKU: 67392-87-4

CAS Number

67392-87-4

LGM Pharma is an API distributor. LGM Pharma supplies APIs as per CGMP with DMF support, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, or pharmacies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:

Drospirenone

CAS Number:

67392-87-4

Indication:

For the prevention of pregnancy in women who elect an oral contraceptive.

Mode of Action:

Progestins such as drospirenone diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge.

Pharmacodynamics:

Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic.

Metabolism:

Extensively metabolized following oral or intravenous administration. The two major metabolites are inactive and are formed independent of the CYP450 enzyme system. The metabolites are the acid form of drospirenone formed by opening of the lactone ring and the 4, 5-dihydro-drospirenone-3-sulfate.

IUPAC:

(1R, 2R, 4R, 10R, 11S, 14S, 15S, 16S, 18S, 19S)-10, 14-dimethylspiro[hexacyclo[9.8.0.0, {2, 4}.0, {5, 10}.0, {14, 19}.0, {16, 18}]nonadecane-15, 2'-oxolan]-5-ene-5', 7-dione

PubChem:

68873

DrugBank:

DB01395

Formula:

C₂₃H₃₁Cl₂NO₃

Molecular Mass:

366.4932

Synonyms:

6_,7_,15_,16_-dimethylene-3-oxo-17_-pregn-4-ene-21,17 carbolactone Drospirenona [inn-spanish] Drospirenonum [inn-latin] DRSP

SMILES:

C[C@]12CC[C@H]3[C@@H]([C@H]4C[C@H]4C4=CC(=O)CC[C@]34C)[C@@H]1[C@@H]1C[C@@H]1[C@@]21CCC(=O)O1

AHFS Code:

68:12:00

InChi:

METQSPRSQINEEU-HXCATZOESA-N

General Reference:

Krattenmacher R: Drospirenone: pharmacology and pharmacokinetics of a unique progestogen. Contraception. 2000 Jul;62(1):29-38. Pubmed

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210.

Ask us about this product

API’s From Quality Manufacturers:

Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
Premium quality GMP certified and fully accredited API manufacturing plants
Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
Regulatory and technical assistance towards any submission type based on specific customer requirements

Drospirenone

67392-87-4

Ask us about this product

API’s From Quality Manufacturers:

Find an API Product