Product Name

Dronabinol

CAS Number

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Product Name:
Dronabinol
CAS Number:
Indication:
For the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments
Mode of Action:

The mechanism of action of marinol is not completely understood. It is thought that cannabinoid receptors in neural tissues may mediate the effects of dronabinol and other cannabinoids. Animal studies with other cannabinoids suggest that marinol's antiemetic effects may be due to inhibition of the vomiting control mechanism in the medulla oblongata.

Pharmacodynamics:

Marinol may has complex effects on the central nervous system (CNS), including cannabinoid receptors. Dronabinol may inhibit endorphins in the emetic center, suppress prostaglandin synthesis, and/or inhibit medullary activity through an unspecified cortical action.

Metabolism:

Hepatic

IUPAC:
(6aR, 10aR)-6, 6, 9-trimethyl-3-pentyl-6H, 6aH, 7H, 8H, 10aH-benzo[c]isochromen-1-ol
ATC:
A04AD10
DrugBank:
DB00470 (APRD00571)
Formula:
C16H11ClN4
Molecular Mass:
314.4617
SMILES:
CCCCCC1=CC(O)=C2[C@@H]3C=C(C)CC[C@H]3C(C)(C)OC2=C1
AHFS Code:
56:22.9
InChi:
CYQFCXCEBYINGO-IAGOWNOFSA-N

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