Product Name

Dipyridamole

CAS Number

58-32-2

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Product Name:
Dipyridamole
CAS Number:
58-32-2
Indication:
For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.
Mode of Action:

Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.

Pharmacodynamics:

Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis.

Metabolism:

hepatic

Toxicity:

Hypotension, if it occurs, is likely to be of short duration, but a vasopressor drug may be used if necessary. The oral LD50 in rats is greater than 6, 000 mg/kg while in the dogs, the oral LD50 is approximately 400 mg/kg. LD50=8.4g/kg (orally in rat)

IUPAC:
2-({6-[bis(2-hydroxyethyl)amino]-4, 8-bis(piperidin-1-yl)pyrimido[5, 4-d][1, 3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol
ATC:
B01AC07 C01DX20
DrugBank:
DB00975 (APRD00360)
Formula:
C17H26N4O
Molecular Mass:
504.6256
Synonyms:
Dipiridamol Dipyridamine Dipyridamol Dipyudamine Dypyridamol Usaf Ge-12
SMILES:
OCCN(CCO)C1=NC2=C(N=C(N=C2N2CCCCC2)N(CCO)CCO)C(=N1)N1CCCCC1
AHFS Code:
24:12.9
InChi:
IZEKFCXSFNUWAM-UHFFFAOYSA-N
General Reference:
General Reference:

  1. Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A: European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996 Nov;143(1-2):1-13. Pubmed

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