Product Name

Dibucaine

CAS Number

85-79-0

LGM Pharma is an API distributor. LGM Pharma can supply CGMP and/or DMF products, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, pharmacies, or any pharmaceutical companies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:
Dibucaine
CAS Number:
85-79-0
Indication:
For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
Mode of Action:

Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions through sodium channel inhibition. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.

Pharmacodynamics:

Dibucaine is an amide-type local anesthetic, similar to lidocaine.

Metabolism:

Primarily hepatic.

Toxicity:

Subcutaneous LD50 in rat is 27 mg/kg. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.

IUPAC:
4-Quinolinecarboxamide, 2-butoxy-N-(2-(diethylamino)ethyl)-
ATC:
C05AD04" D04AB02" N01BB06" S01HA06" S02DA04
DrugBank:
DB00527 (APRD00915)
Formula:
C20-H29-N3-O2
Molecular Mass:
343.4681
Synonyms:
2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide, 2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide, 2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide, 2-N-Butoxy-N-(2-diethylaminoethyl)cinchoninamide, 4-22-00-02284 (Beilstein Handbook Reference), 4-Quinolinecarboxamide, 2-butoxy-N-(2-(diethylamino)ethyl)-, alpha-Butyloxycinchonic acid-gamma-diethylethylenediamine, alpha-Butyloxycinchoninic acid diethylethylenediamide, BRN 0275489, Cincainum, Cinchocaine, Cinchocainum, Cinchocainum [INN-Latin], Cinchoninamide, 2-butoxy-N-(2-(diethylamino)ethyl)-, Cincocaina, Cincocaina [DCIT], Cincocainio, Cincocainio [INN-Spanish], Dermacaine, Dibucain, Dibucaine, Dibucaine Base, Dibucainum, EINECS 201-632-1, HSDB 3312, N-(2-(Diethylamino)ethyl)-2-butoxycinchoninamide, NSC 159055, Nupercainal, Nupercainal (VAN), Nupercaine, Percamine, Sovcaine, UNII-L6JW2TJG99
SMILES:
c12c(cc(nc1cccc2)OCCCC)C(=O)NCCN(CC)CC
AHFS Code:
24:08.0
InChi:
1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24)
General Reference:
General Reference:

  1. Abdel-Ghani NT, Youssef AF, Awady MA: Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry. Farmaco. 2005 May;60(5):419-24. Pubmed
  2. Souto-Padron T, Lima AP, Ribeiro Rde O: Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. Parasitol Res. 2006 Sep;99(4):317-20. Epub 2006 Apr 13. Pubmed
  3. Nounou MM, El-Khordagui LK, Khalafallah N: Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles. Acta Pol Pharm. 2005 Sep-Oct;62(5):369-79. Pubmed

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210. 

Ask us about this product

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants
  • Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any submission type based on specific customer requirements

Find an API Product

SEARCH
Generic filters