Product Name

Desoximetasone

CAS Number

382-67-2

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Product Name:
Desoximetasone
CAS Number:
382-67-2
Indication:
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Mode of Action:

The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A_ inhibitory proteins, collectively called lipocortins. This is achieved first by the drug binding to the glucocorticoid receptors which then translocates into the nucleus and binds to DNA causing various activations and repressions of genes. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A_.

Pharmacodynamics:

Like other topical corticosteroids, desoximetasone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Desoximetasone is a potent topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.

Metabolism:

Metabolized, primarily in the liver, and then excreted by the kidneys.

Toxicity:

Topically applied desoximetasone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).

IUPAC:
(1R, 2S, 10S, 11S, 13R, 14S, 15S, 17S)-1-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2, 13, 15-trimethyltetracyclo[8.7.0.0, {2, 7}.0, {11, 15}]heptadeca-3, 6-dien-5-one
ATC:
D07AC03 D07XC02
PubChem:
5311067
DrugBank:
DB00547 (APRD00910)
Formula:
C24H40N8O4
Molecular Mass:
376.4617
SMILES:
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO
AHFS Code:
24:06.0
InChi:
VWVSBHGCDBMOOT-IIEHVVJPSA-N

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