Product Name

Desonide

CAS Number

638-94-8

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Product Name:
Desonide
CAS Number:
638-94-8
Indication:
For the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatose.
Mode of Action:

Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The drug binds to cytosolic glucocorticoid receptors. This complex migrates to the nucleus and binds to genetic elements on the DNA. This activates and represses various genes. However corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

Pharmacodynamics:

Desonide is a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents.

IUPAC:
(1S, 2S, 4R, 8S, 9S, 11S, 12S, 13R)-11-hydroxy-8-(2-hydroxyacetyl)-6, 6, 9, 13-tetramethyl-5, 7-dioxapentacyclo[10.8.0.0, {2, 9}.0, {4, 8}.0, {13, 18}]icosa-14, 17-dien-16-one
ATC:
D07AC09 R03BA02 S01BA11 A07EA06 D07AB08 R01AD05
PubChem:
12536
DrugBank:
DB01260
Formula:
C19H29NO5
Molecular Mass:
416.5073
SMILES:
CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO
AHFS Code:
24:06.0
InChi:
WBGKWQHBNHJJPZ-LECWWXJVSA-N

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