Product Name

Desonide

Name: Desonide - LGM Pharma
SKU: 638-94-8

CAS Number

638-94-8

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Product Name:

Desonide

CAS Number:

638-94-8

Indication:

For the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatose.

Mode of Action:

Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The drug binds to cytosolic glucocorticoid receptors. This complex migrates to the nucleus and binds to genetic elements on the DNA. This activates and represses various genes. However corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

Pharmacodynamics:

Desonide is a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents.

IUPAC:

(1S, 2S, 4R, 8S, 9S, 11S, 12S, 13R)-11-hydroxy-8-(2-hydroxyacetyl)-6, 6, 9, 13-tetramethyl-5, 7-dioxapentacyclo[10.8.0.0, {2, 9}.0, {4, 8}.0, {13, 18}]icosa-14, 17-dien-16-one

ATC:

D07AC09 R03BA02 S01BA11 A07EA06 D07AB08 R01AD05

PubChem:

12536

DrugBank:

DB01260

Formula:

C₁₉H₂₉NO₅

Molecular Mass:

416.5073

SMILES:

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO

AHFS Code:

24:06.0

InChi:

WBGKWQHBNHJJPZ-LECWWXJVSA-N

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Desonide

638-94-8

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