Product Name

Desmopressin Acetate

Name: Desmopressin Acetate
SKU: 62288-83-9

CAS Number

62288-83-9

LGM Pharma is an API distributor. LGM Pharma can supply CGMP and/or DMF products, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, pharmacies, or any pharmaceutical companies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:

Desmopressin Acetate

CAS Number:

62288-83-9

Indication:

Oral formulations may be used to manage primary nocturnal enuresis in adults and vasopressin sensitive diabetes insipidus, and for control of temporary polyuria and polydipsia following head trauma or surgery in the pituitary region. Intranasal and parenteral formulations may be used to manage spontaneous or trauma-induced bleeds (e.g. hemarthrosis, intramuscular hematoma, mucosal bleeding) in patients with hemophilia A or von Willebrand’s disease Type I. May also be used parenterally to prevent or treat bleeding in patients with uremia.

Mode of Action:

Desmopressin emulates the actions of endogenous human ADH (refer to Pharmacology section above). Desmpressin is a structural analogue of ADH modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. Compared to natural ADH, desmopressin elicits a great antidiuretic response on weight basis.

Pharmacodynamics:

Desmopressin is a synthetic analogue of the natural antidiuretic hormone (ADH or vasopressin) that is produced by the hypothalamus and stored in the posterior pituitary gland. The main function of ADH is to regulate extracellular fluid volume in the body. ADH secretion is stimulated by angiotensin II, linking it to the renin-angiotensin-aldosterone system (RAAS). ADH stimulates water reabsorption in the kidneys by causing the insertion of aquaporin-2 channels on the apical surface of cells of the DCT and collecting tubules. It also causes vasoconstriction through its action on vascular smooth muscle cells of the collecting tubules. The efficacy of desmopressin for managing bleeds in patients with hemophilia A or von Willebrand’s disease Type I arises from its ability to elicit dose-dependent increases in plasma factor VIII (antihemophilic factor), plasminogen activator, and to a lesser extent, factor VIII-related antigen and ristocetin cofactor activities; these changes improve blood clotting.

Metabolism:

Metabolic fate unknown. Is not affected by liver microsomal cytochrome P450 enzymes.

Toxicity:

Overdose may lead to increased duration of action and lead to symptoms such as fluid retention, headaches, abdominal cramps, nausea, and facial flushing. Adverse effects include headache, nausea, abdominal pain, facial flushing, dizziness, dry mouth, and hyponatremia. Nasal congestion and rhinitis have been reported with nasal spray formulations.

IUPAC:

Vasopressin, 1-(3-mercaptopropanoic acid)-8-D-arginine-, monoacetate (salt)

ATC:

H01BA02

PubChem:

5311065

DrugBank:

DB00035 (BIOD00061, BIOD00112, BTD00061, BTD00112)

Formula:

C46-H64-N14-O12-S2.C2-H4-O2

Molecular Mass:

1129.28

Synonyms:

1-(3-Mercaptopropionic acid)-8-D-arginine vasopression monoacetate, Concentraid, DDAVP, DDAVP (needs no refrigeration), DDAVP Nasal Spray, DDAVP Rhinal Tube, Demopressin acetate, Desmopressin acetate, Desmopressin acetate (needs NO refrigeration), Desmopressin acetate preservative free, Minirin, Minirine, Octostim, Stimate, Stimate Nasal Spray, UNII-1K12647SFC

SMILES:

N1(CCC[C@@H]1C(=O)N[C@@H](C(NCC(N)=O)=O)CCCNC(N)=N)C([C@@H]1CSSCCC(N[C@@H](C(N[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(N)=O)C(N1)=O)Cc1ccccc1)=O)Cc1ccc(cc1)O)=O)=O.CC(O)=O

AHFS Code:

08:28.0

General Reference:

Leissinger C, Becton D, Cornell C Jr, Cox Gill J: High-dose DDAVP intranasal spray (Stimate) for the prevention and treatment of bleeding in patients with mild haemophilia A, mild or moderate type 1 von Willebrand disease and symptomatic carriers of haemophilia A. Haemophilia. 2001 May;7(3):258-66. Pubmed
Sequence Information Link

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210.

Ask us about this product

API’s From Quality Manufacturers:

Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
Premium quality GMP certified and fully accredited API manufacturing plants
Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
Regulatory and technical assistance towards any submission type based on specific customer requirements

Desmopressin Acetate

62288-83-9

Ask us about this product

API’s From Quality Manufacturers:

Find an API Product