Product Name

Desflurane

CAS Number

57041-67-5

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Product Name:
Desflurane
CAS Number:
57041-67-5
Indication:
For use as an inhalation agent for induction and/or maintenance of anesthesia for inpatient and outpatient surgery in adults.
Mode of Action:

Desflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Desflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Desflurane also binds to and agonizes the GABA receptor, the large conductance Ca2+ activated potassium channel, the glycine receptors, and antagonizes the glutamate receptors.

Pharmacodynamics:

Desflurane is a general inhalation anesthetic. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.

Metabolism:

Minimally biotransformed in the liver in humans (approximately 0.02% of the quantity absorbed).

IUPAC:
2-(difluoromethoxy)-1, 1, 1, 2-tetrafluoroethane
ATC:
N01AB07
PubChem:
42113
DrugBank:
DB01189 (APRD00907)
Formula:
C41H64O14
Molecular Mass:
168.0378
Synonyms:
Desflurano [INN-Spanish] Desfluranum [INN-Latin]
SMILES:
FC(F)OC(F)C(F)(F)F
AHFS Code:
28:04.0
InChi:
DPYMFVXJLLWWEU-UHFFFAOYSA-N

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