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Crisaborole

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Product Details:

  • Product Name: Crisaborole
  • Mode of Action:

    It is a phosphodiesterase-4 inhibitor, mainly acting on phosphodiesterase 4B (PDE4B), which causes inflammation. Chemically, crisaborole is a phenoxybenzoxaborole. It contains a boron atom that helps penetrate the skin and is essential for its binding activity. Inhibition of PDE4B appears to suppress the release of tumor necrosis factor alpha (TNFα), interleukin-12 (IL-12), IL-23 and other cytokines, proteins believed to be involved in the immune response and inflammation.

  • PubChem: 44591583
  • DrugBank: DB05219
  • Formula: C14H10BNO3
  • Molecular Mass: 251.045100 g/mol
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