Product Name

Cinnarizine

CAS Number

298-57-7

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Product Name:
Cinnarizine
CAS Number:
298-57-7
Indication:
For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
Mode of Action:

Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. Cinnarizine has also been implicated in binding to dopamine D2 receptors, histamine H1 receptors, and muscarinic acetylcholine receptors.

Pharmacodynamics:

Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system.

IUPAC:
1-(diphenylmethyl)-4-(3-phenylprop-2-en-1-yl)piperazine
ATC:
N07CA02
PubChem:
2761
DrugBank:
DB00568 (APRD00332)
Formula:
C22H17ClN2
Molecular Mass:
368.5139
SMILES:
C(C=CC1=CC=CC=C1)N1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1
InChi:
DERZBLKQOCDDDZ-JLHYYAGUSA-N

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