Product Name

Cilazapril

Name: Cilazapril - LGM Pharma
SKU: 92077-78-6

CAS Number

92077-78-6

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Product Name:

Cilazapril

CAS Number:

92077-78-6

Indication:

Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure.

Mode of Action:

Cilazapril is a pyridazine ACE inhibitor. It competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II levels results in a decrease in blood pressure, an increase in renin activity, and stimulation of baroreceptor reflex mechanisms. Kininase II, an enzyme which degrades the vasodilator bradykinin, is identical to ACE and may also be inhibited.

Pharmacodynamics:

Cilazapril inhibits the production angiotensin II. By doing so, it decreases sodium and water reabsorption (via aldosterone) and it decreases vasoconstriction. The combined effect of this is a decrease in vascular resistance, and therefore, blood pressure.

IUPAC:

(1S, 9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxo-octahydro-1H-pyridazino[1, 2-a][1, 2]diazepine-1-carboxylic acid

ATC:

C09AA08

PubChem:

56330

DrugBank:

DB01340

Formula:

C₁₂H₁₅ClO₃

Molecular Mass:

417.4986

Synonyms:

Inhibace

SMILES:

CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]1CCCN2CCC[C@H](N2C1=O)C(O)=O

AHFS Code:

24:32.0

InChi:

HHHKFGXWKKUNCY-FHWLQOOXSA-N

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Cilazapril

92077-78-6

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