• # LGM Pharma is a Chlorpromazine CAS# 50-53-3 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
  • # Questions? Call our customer API support number 1-(800)-881-8210.
  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
  • Inquire about this product >>

Product Details:

  • Product Name: Chlorpromazine
  • CAS #: 50-53-3
  • Mode of Action:

    Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects). Additionally, Chlorpromazine is a weak presynaptic inhibitor of Dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use).

  • Pharmacodynamics:

    Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Chlorpromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Chlorpromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.

  • Metabolism:

    Extensively metabolized in the liver and kidneys. It is extensively metabolized by cytochrome P450 isozymes CYP2D6 (major pathway), CYP1A2 and CYP3A4. Approximately 10 to 12 major metabolite have been identified. Hydroxylation at positions 3 and 7 of the phenothiazine nucleus and the N-dimethylaminopropyl side chain undergoes demethylation and is also metabolized to an N-oxide. In urine, 20% of chlopromazine and its metabolites are excreted unconjugated in the urine as unchanged drug, demonomethylchlorpromazine, dedimethylchlorpromazine, their sulfoxide metabolites, and chlorpromazine-N-oxide. The remaining 80% consists of conjugated metabolites, principally O-glucuronides and small amounts of ethereal sulfates of the mono- and dihydroxy-derivatives of chlorpromazine and their sulfoxide metabolites. The major metabolites are the monoglucuronide of N-dedimethylchlorpromazine and 7-hydroxychlorpromazine. Approximately 37% of the administered dose of chlorpromazine is excreted in urine.

  • Toxicity:

    Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness

  • IUPAC: [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine
  • ATC: N05AA01
  • PubChem: https://www.ncbi.nlm.nih.gov/pcsubstance?term=50-53-3~%5Bsynonym%5D
  • DrugBank: DB00477 (APRD00482)
  • Formula: C17-H19-Cl-N2-S
  • Molecular Mass: 318.8701
  • Synonyms: 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine, 2-Chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine, 2-Chloropromazine, 2-Cloro-10 (3-dimetilaminopropil)fenotiazina, 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian], 4560 R.P., Aminazin, Aminazine, Ampliactil, BC 135, CCRIS 3711, Chlor-Promanyl, Chlorderazin, Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine, Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French], Chloropromazine, Chlorpromados, Chlorpromazin, Chlorpromazine, Chlorpromazinum, Chlorpromazinum [INN-Latin], Clorpromazina, Clorpromazina [INN-Spanish], Clorpromazina [Italian], Contomin, CPZ, EINECS 200-045-8, Elmarin, Esmind, Fenactil, Fenaktyl, Fraction AB, GG 407, HL 5746, HSDB 3033, Largactil, Largactilothiazine, Largactyl, Megaphen, N-(3-Dimethylaminopropyl)-3-chlorophenothiazine, Novomazina, NSC 167745, Phenactyl, Proma, Promactil, Promazil, Propaphenin, Prozil, Psychozine, Sanopron, SKF 2601-A, Thorazine, Thorazine Suppositories, Torazina, UNII-U42B7VYA4P, Wintermin
  • SMILES: CN(C)CCCN1c2ccccc2Sc3c1cc(cc3)Cl
  • AHFS Code: 28:16.08.24
  • InChl: 1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
  • General Reference:

    1. Leucht S, Wahlbeck K, Hamann J, Kissling W: New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis. Lancet. 2003 May 10;361(9369):1581-9. Pubmed

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants

 

  • Technical packages as well as access to filed DMF,
    ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any
    submission type based on specific customer requirements

LGM Pharma Acquires CDMO

On July 27, 2020, LGM Pharma announced its acquisition of the formulation development and drug product contract manufacturing business of Nexgen Pharma, Inc. As a result, you will notice our new logo and visuals throughout the website. We’re working on updates to reflect the exciting, expanded CDMO capabilities and services we now can offer you.

This website uses cookies. By using our site, you agree to our terms of service