Chlorhexidine Acetate

  • # LGM Pharma is a Chlorhexidine Acetate CAS# 56-95-1 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
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  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
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Product Details:

  • Product Name: Chlorhexidine Acetate
  • CAS #: 56-95-1
  • Mode of Action:

    Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms.

  • Pharmacodynamics:

    Chlorhexidine, a topical antimicrobial agent, is bactericidal. Because of its positive charge, the chlorhexidine molecule reacts with the microbial cell surface to destroy the integrity of the cell membrane. This novel mechanism of action makes it highly unlikely for the development of bacterial resistance.

  • Toxicity:

    LD50= 2g/kg (human, oral); LD50= 3 g/kg (rat, oral); LD50= 2.5 g/kg (mice, oral); LD50= 21 mg/kg (male rat, IV); LD50= 23 mg/kg (female rat, IV); LD50= 25 mg/kg (male mice, IV); LD50= 24 mg/kg (female mice, IV); LD50= 1g/kg (rat, subcutaneous); LD50= 637 mg/kg (male mice, subcutaneous); LD50= 632 mg/kg (female mice, subcutaneous)

  • ATC: A01AB03" B05CA02" D08AC02" D09AA12" R02AA05" S01AX09" S02AA09" S03AA04
  • DrugBank: DB00878 (APRD00545)
  • Formula: C22-H30-Cl2-N10.2C2-H4-O2
  • Molecular Mass: 625.5582
  • Synonyms: 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) diacetate, 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) diacetate, 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide)diacetate, 1,6-Bis(5-(p-chlorophenyl)biguandino)hexane diacetate, 1,6-Bis(p-chlorophenylbiguanido)hexane diacetate, 1,6-Di(4'-chlorophenyldiguanidino)hexane diacetate, 10,040 Diacetate, Bactigras, Bis(p-chlorophenyldiguanidohexane) diacetate, Caswell No. 481E, Chlorhexidine acetate, Chlorhexidine acetate (VAN), Chlorhexidine diacetate, Chlorohexidine diacetate, EINECS 200-302-4, EPA Pesticide Chemical Code 045502, Hibitane diacetate, Nolvasan, NSC 526936, UNII-5908ZUF22Y
  • SMILES: CC(=O)O.CC(=O)O.c1cc(ccc1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(cc2)Cl)Cl
  • AHFS Code: 34:00.00, 52:04.92, 84:04.92
  • InChl: 1S/C22H30Cl2N10.2C2H4O2/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*1-2(3)4/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H3,(H,3,4)
  • General Reference:

    McBain AJ, Bartolo RG, Catrenich CE, Charbonneau D, Ledder RG, Gilbert P: Effects of a chlorhexidine gluconate-containing mouthwash on the vitality and antimicrobial susceptibility of in vitro oral bacterial ecosystems. Appl Environ Microbiol. 2003 Aug;69(8):4770-6. Pubmed

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LGM Pharma Acquires CDMO

On July 27, 2020, LGM Pharma announced its acquisition of the formulation development and drug product contract manufacturing business of Nexgen Pharma, Inc. As a result, you will notice our new logo and visuals throughout the website. We’re working on updates to reflect the exciting, expanded CDMO capabilities and services we now can offer you.

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