Product Name

Cephalexin

CAS Number

15686-71-2

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Product Name:
Cephalexin
CAS Number:
15686-71-2
Indication:
For the treatment of respiratory tract infections caused by Streptococcus pneumoniae and Streptococcus pyogenes; otitis media due to Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Moraxella catarrhalis; skin and skin structure infections caused by Staphylococcus aureus and/or Streptococcus pyogenes; bone infections caused by Staphylococcus aureus and/or Proteus mirabilis; genitourinary tract infections, including acute prostatitis, caused by Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae.
Mode of Action:

Cephalexin, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin interferes with an autolysin inhibitor.

Pharmacodynamics:

Cephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic. It is one of the most widely prescribed antibiotics, often used for the treatment of superficial infections that result as complications of minor wounds or lacerations. It is effective against most gram-positive bacteria.

Metabolism:

No appreciable biotransformation in the liver (90% of the drug is excreted unchanged in the urine).

Toxicity:

Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting. The oral median lethal dose of cephalexin in rats is >5000 mg/kg.

IUPAC:
(6R, 7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
ATC:
J01DB01
PubChem:
2666
DrugBank:
DB00567 (APRD00250)
Formula:
C23H29ClFN3O4
Molecular Mass:
347.389
Synonyms:
Cefalessina [DCIT] Cefalexin Cefalexin Sodium Cefalexina [INN-Spanish] Cefalexine [INN-French] Cefalexinum [INN-Latin] Cephalexin 1-hydrate Cephalexin hydrate Cephalexin monohydrate Cephalexine Cephalexinum CEX
SMILES:
CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)C1=CC=CC=C1)C2=O)C(O)=O
AHFS Code:
08:12.06.04
InChi:
ZAIPMKNFIOOWCQ-UEKVPHQBSA-N

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Questions? Call our customer API support number 1-(800)-881-8210. 

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