Product Name

Cefdinir

CAS Number

91832-40-5

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Product Name:
Cefdinir
CAS Number:
91832-40-5
Indication:
For the treatment of the respiratory, skin, soft tissue, and ENT infections caused by H. influenzae (including b-lactamase producing strains), H. parainfluenzae (including b-lactamase producing strains), S. pneumoniae (penicillin-susceptible strains), S. pyogenes, S. aureus (including b-lactamase producing strains), and M. catarrhalis.
Mode of Action:

As with other cephalosporins, bactericidal activity of cefdinir results from inhibition of cell wall synthesis by acting on penicillin binding proteins (PBPs).

Pharmacodynamics:

Cefdinir is a third generation cephalosporin with a broad spectrum of activity against enteric gram-negative rods. Cefdinir is stable in the presence of some, but not all, b-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins are susceptible to cefdinir. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal.

Metabolism:

Cefdinir is not appreciably metabolized. Activity is primarily due to parent drug.

Toxicity:

Information on cefdinir overdosage in humans is not available. In acute rodent toxicity studies, a single oral 5600-mg/kg dose produced no adverse effects. Toxic signs and symptoms following overdosage with other b-lactam antibiotics have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.

IUPAC:
(6R, 7R)-7-[(2Z)-2-(2-amino-1, 3-thiazol-4-yl)-2-(N-hydroxyimino)acetamido]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
ATC:
J01DD15
PubChem:
6915944
DrugBank:
DB00535 (APRD00644)
Formula:
C22H31N3O5
Molecular Mass:
395.414
Synonyms:
Cefdirnir CFDN
SMILES:
NC1=NC(=CS1)C(=NO)C(=O)N[C@H]1[C@H]2SCC(C=C)=C(N2C1=O)C(O)=O
InChi:
RTXOFQZKPXMALH-GHXIOONMSA-N
General Reference:
General Reference:

  1. Yamanaka H, Shimazaki J, Imai K, Sugiyama Y, Shida K: Effect of estrogen administration on activities of testosterone 5alpha-reductase, alkaline phosphatase and arginase in the ventral and the dorsolateral prostates of rats. Endocrinol Jpn. 1975 Aug;22(4):297-302. Pubmed

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