Product Name

Carbimazole

Name: Carbimazole - LGM Pharma
SKU: 22232-54-8

CAS Number

22232-54-8

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Product Name:

Carbimazole

CAS Number:

22232-54-8

Indication:

For the treatment of hyperthyroidism and thyrotoxicosis. It is also used to prepare patients for thyroidectomy.

Mode of Action:

Carbimazole is an aitithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine. Once converted to its active form of methimazole, it prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4.

Pharmacodynamics:

Carbimazole is a carbethoxy derivative of methimazole. Its antithyroid action is due to its conversion to methimazole after absorption. It is used to treat hyperthyroidism and thyrotoxicosis.

IUPAC:

ethyl 3-methyl-2-sulfanylidene-2, 3-dihydro-1H-imidazole-1-carboxylate

ATC:

H03BB01

PubChem:

31072

DrugBank:

DB00389 (APRD00503)

Formula:

C₁₄H₁₉Cl₂NO₂

Molecular Mass:

186.232

Synonyms:

Athyromazole Carbethoxymethimazole Carbimazol Carbimazol [INN-Spanish, French] Carbimazolum [INN-Latin] Carbinazole

SMILES:

CCOC(=O)N1C=CN(C)C1=S

InChi:

CFOYWRHIYXMDOT-UHFFFAOYSA-N

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Carbimazole

22232-54-8

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