Product Name

Carbamazepine

CAS Number

298-46-4

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Product Name:
Carbamazepine
CAS Number:
298-46-4
Indication:
For the treatment of epilepsy and pain associated with true trigeminal neuralgia.
Mode of Action:

Carbamazepine inhibits sustained repetitive firing by blocking use-dependent sodium channels. Pain relief is believed to be associated with blockade of synaptic transmission in the trigeminal nucleus and seizure control with reduction of post-tetanic potentiation of synaptic transmission in the spinal cord. Carbamazepine also possesses anticholinergic, central antidiuretic, antiarrhythmic, muscle relaxant, antidepressant (possibly through blockade of norepinephrine release), sedative, and neuromuscular-blocking properties.

Pharmacodynamics:

Carbamazepine, an anticonvulsant structurally similar to tricyclic antidepressants, is used to treat partial seizures, tonic-clonic seizures, pain of neurologic origin such as trigeminal neuralgia, and psychiatric disorders including manic-depressive illness and aggression due to dementia.

Metabolism:

Hepatic

Toxicity:

Mild ingestions cause vomiting, drowsiness, ataxia, slurred speech, nystagmus, dystonic reactions, and hallucinations. Severe intoxications may produce coma, seizures, respiratory depression, and hypotension

IUPAC:
2-azatricyclo[9.4.0.0, {3, 8}]pentadeca-1(11), 3(8), 4, 6, 9, 12, 14-heptaene-2-carboxamide
ATC:
N03AF01
PubChem:
2554
DrugBank:
DB00564 (APRD00337)
Formula:
C70H92ClN17O14
Molecular Mass:
236.2686
Synonyms:
Carbamezepine
SMILES:
NC(=O)N1C2=CC=CC=C2C=CC2=CC=CC=C12
AHFS Code:
28:12.9
InChi:
FFGPTBGBLSHEPO-UHFFFAOYSA-N

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