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Product Details:

  • Product Name: Cabozantinib
  • CAS #: 849217-68-1
  • Mode of Action:

    Cabozantinib inhibits specific receptor tyrosine kinases such as VEGFR-1, -2 and -3, KIT, TRKB, FLT-3, AXL, RET, MET, and TIE-2.

  • Pharmacodynamics:

    Cabozantinib suppresses metastasis, angiogenesis, and oncognesis by inhibiting receptor tyrosine kinases.

  • Metabolism:

    Cabozantinib is metabolized mostly by CYP3A4 and, to a minor extent, by CYP2C9. Both enzyme produce an N-oxide metabolite.

  • Toxicity:

    Cabozantinib has a black box warning of serious gastrointestinal fistulas and perforations, and potentially fatal hemoptysis and gastrointestinal hemorrhage.

  • IUPAC: 1, 1-Cyclopropanedicarboxamide, N'-(4-((6, 7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4- fluorophenyl)-
  • DrugBank: DB08875
  • Formula: C28H24FN3O5
  • Molecular Mass: 501.5
  • Synonyms: BMS 907351, Cabozantinib, Cometriq, UNII-1C39JW444G, XL 184, XL-184, XL184
  • SMILES: COc1cc2c(ccnc2cc1OC)Oc3ccc(cc3)NC(=O)C4(CC4)C(=O)Nc5ccc(cc5)F
  • InChl: InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
  • General Reference:


    1. Durante C, Russo D, Verrienti A, Filetti S: XL184 (cabozantinib) for medullary thyroid carcinoma. Expert Opin Investig Drugs. 2011 Mar;20(3):407-413. doi: 10.1517/13543784.2011.559163. Pubmed


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