Product Name

Bicalutamide

CAS Number

90357-06-05

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Product Name:
Bicalutamide
CAS Number:
90357-06-05
Indication:
For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
Mode of Action:

Bicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue.

Pharmacodynamics:

Bicalutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Bicalutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Bicalutamide blocks the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.

Metabolism:

Bicalutamide undergoes stereo specific metabolism. The S (inactive) isomer is metabolized primarily by glucuronidation. The R (active) isomer also undergoes glucuronidation but is predominantly oxidized to an inactive metabolite followed by glucuronidation.

IUPAC:
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorobenzene)sulfonyl]-2-hydroxy-2-methylpropanamide
ATC:
L02BB03
PubChem:
2375
DrugBank:
DB01128 (APRD00042, DB06284)
Molecular Mass:
430.373
SMILES:
CC(O)(CS(=O)(=O)C1=CC=C(F)C=C1)C(=O)NC1=CC(=C(C=C1)C#N)C(F)(F)F
AHFS Code:
10:00.0
InChi:
LKJPYSCBVHEWIU-UHFFFAOYSA-N

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