Product Name

Betamethasone

CAS Number

378-44-9

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Product Name:
Betamethasone
CAS Number:
378-44-9
Indication:
Topical use (cream, lotion and ointment): for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatosesTopical use (foam): relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalpSystemic use: for the treatment of edocrine disorders, rheumatic disorders, collagen diseases, dermatological diseases, allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, gastrointestinal diseases, tuberculous meningitis and trichinosis.
Mode of Action:

Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.

Pharmacodynamics:

Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties, betamethasone is combined with a mineralocorticoid to manage adrenal insufficiency and is used in the form of betamethasone benzoate, betamethasone dipropionate, or betamethasone valerate for the treatment of inflammation due to corticosteroid-responsive dermatoses. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections.

Metabolism:

Hepatic

Toxicity:

Symptoms of overdose include burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.

IUPAC:
(1R, 2S, 10S, 11S, 13S, 14R, 15S, 17S)-1-fluoro-14, 17-dihydroxy-14-(2-hydroxyacetyl)-2, 13, 15-trimethyltetracyclo[8.7.0.0, {2, 7}.0, {11, 15}]heptadeca-3, 6-dien-5-one
ATC:
A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03
PubChem:
9782
DrugBank:
DB00443 (APRD00513)
Formula:
C25H34O6
Molecular Mass:
392.4611
SMILES:
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
AHFS Code:
24:06.0
InChi:
UREBDLICKHMUKA-DVTGEIKXSA-N

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