• # LGM Pharma is a Amsacrine CAS# 51264-14-3 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, samples, sourcing, purity and more.
  • # Questions? Call our customer API support number 1-(800)-881-8210.
  • # LGM Pharma offers this active ingredient but not the finished dosage forms.
  • Inquire about this product >>

Product Details:

  • Product Name: Amsacrine
  • CAS #: 51264-14-3
  • Mode of Action:

    Amsacrine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive to amsacrine than are resting cells. Amsacrine appears to cleave DNA by inducing double stranded breaks. Amsacrine also targets and inhibits topoisomerase II. Cytotoxicity is greatest during the S phase of the cell cycle when topoisomerase levels are at a maximum.

  • Pharmacodynamics:

    Amsacrine is an aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.

  • Metabolism:

    Extensive, primarily hepatic, converted to glutathione conjugate.

  • Toxicity:

    Symptoms of overdose include nausea and vomiting, diarrhea, some cardiotoxicity (rarely).

  • IUPAC: N-{4-[(acridin-9-yl)amino]-3-methoxyphenyl}methanesulfonamide
  • ATC: L01XX01
  • PubChem: 2179
  • DrugBank: DB00276 (APRD00064)
  • Formula: C10H12ClNO2
  • Molecular Mass: 393.459
  • Synonyms: Acridinyl Anisidide M-AMSA MAMSA
  • SMILES: COC1=C(NC2=C3C=CC=CC3=NC3=CC=CC=C23)C=CC(NS(C)(=O)=O)=C1
  • AHFS Code: 10:00.0
  • InChl: XCPGHVQEEXUHNC-UHFFFAOYSA-N
  • General Reference:

    1. Link

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants

 

  • Technical packages as well as access to filed DMF,
    ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any
    submission type based on specific customer requirements

LGM Pharma Acquires CDMO

On July 27, 2020, LGM Pharma announced its acquisition of the formulation development and drug product contract manufacturing business of Nexgen Pharma, Inc. As a result, you will notice our new logo and visuals throughout the website. We’re working on updates to reflect the exciting, expanded CDMO capabilities and services we now can offer you.

This website uses cookies. By using our site, you agree to our terms of service