Product Name

Amlodipine Besylate

CAS Number

111470-99-6

LGM Pharma is an API distributor. LGM Pharma can supply CGMP and/or DMF products, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, pharmacies, or any pharmaceutical companies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:
Amlodipine Besylate
CAS Number:
111470-99-6
Mode of Action:

L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM).

IUPAC:
2-[(2-Aminoethoxy)methyl]-4-(2-chlo rophenyl)-1, 4-dihydro-6-methyl-3, 5-pyridinedicarbo xylic acid 3-ethyl 5-methyl ester benzenesulfonate
ATC:
C08CA01
PubChem:
60496
DrugBank:
APRD00520
Formula:
C20H25ClN2O5.C6H6O3S
Molecular Mass:
567.05
Synonyms:
2-[(2-AMINOETHOXY)-METHYL]-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER BENZENE SULFONATE, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate, AMLODIPINE BENZENESULFONATE, AMLODIPINE BESILATE, AMLODIPINE BESYLATE, NORVASC, 3,5-pyridinedicarboxylicacid,2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1, 4-dihydro-6-methyl-,3-ethyl-5-methylester,monobenzenesulfonate, AMLODIPINE BESILATE MM(CRM STANDARD), AMLODIPINE BESYLATE EPY(CRM STANDARD), 2-[(2-aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate, AMLODIPINEBESYLATE(SUBJECTTOPATENTFREE), (+-)-3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate monobenzenesulfonate, 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, monobenzenesulfonate, Amcard, Amdepin, Amdipin, Amlodin, Amlopin, Amlor
General Reference:
General Reference:
  1. Arrowsmith, J.E., et al. 1986. J. Med. Chem. 29: 1696-1702. PMID: 2943898
  2. Burges, R.A., et al. 1987. J. Cardiovasc. Pharmacol. 9: 110-119. PMID: 2434785
  3. Packer, M., et al. 1996. N. Engl. J. Med. 335: 1107-1114. PMID: 8813041
  4. Yoshida, J., et al. 2003. Eur. J. Pharmacol. 472: 23-31. PMID: 12860469
  5. Toba, H., et al. 2005 Hypertens. Res. 28: 689-700. PMID: 16392774

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210. 

Ask us about this product

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants
  • Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any submission type based on specific customer requirements

Find an API Product

SEARCH
Generic filters