Product Name

Almotriptan Malate

Name: Almotriptan Malate - LGM Pharma
SKU: 181183-52-8

CAS Number

181183-52-8

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Product Name:

Almotriptan Malate

CAS Number:

181183-52-8

Indication:

For the treatment of acute migraine headache in adults

Mode of Action:

Almotriptan binds with high affinity to human 5-HT_1B and 5-HT_1D receptors leading to cranial blood vessel constriction.

Pharmacodynamics:

Almotriptan is a selective 5-hydroxytryptamine receptor subtype agonist indicated for the acute treatment of migraine attacks with or without aura in adults. Almotriptan is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine. Almotriptan is an agonist for a vascular 5-hydroxytryptamine receptor subtype (probably a member of the 5-HT_1D family) having only a weak affinity for 5-HT_1A, 5-HT_5A, and 5-HT₇ receptors and no significant affinity or pharmacological activity at 5-HT₂, 5-HT₃ or 5-HT₄ receptor subtypes or at alpha1-, alpha2-, or beta-adrenergic, dopamine1, ; dopamine2; muscarinic, or benzodiazepine receptors. This action in humans correlates with the relief of migraine headache. In addition to causing vasoconstriction, experimental data from animal studies show that Almotriptan also activates 5-HT₁ receptors on peripheral terminals of the trigeminal nerve innervating cranial blood vessels, which may also contribute to the antimigrainous effect of Almotriptan in humans.

IUPAC:

Butanedioic acid, hydroxy-, compd. with 1-(((3-(2- (dimethylamino)ethyl)-1H-indol-5- yl)methyl)sulfonyl)pyrrolidine (1:1)

ATC:

N02CC05

PubChem:

123606

DrugBank:

DB00918

Formula:

C₁₇H₂₅N₃O₂S.C₄H₆O₅

Molecular Mass:

335.464

Synonyms:

1-(((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)sulfonyl)pyrrolidine, hydroxybutanedioate (1:1), 1-(((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)sulfonyl)pyrrolidine, hydroxybutanedionate (1:1), 1-(((3-(2-(Dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidine malate (1:1), Almotriptan malate, Axert, LAS 31416 D,L-malate acid, PNU 180638E, PNU-180638E, UNII-PJP312605E,

SMILES:

c1cc2[nH]cc(c2cc1CS(N1CCCC1)(=O)=O)CCN(C)C.OC([C@@H](CC(O)=O)O)=O

AHFS Code:

28:32.3

InChi:

InChI=1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)

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Almotriptan Malate

181183-52-8

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