Product Name

Alizapride

CAS Number

59338-93-1

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Product Name:
Alizapride
CAS Number:
59338-93-1
Indication:
Alizapride is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.
Mode of Action:

The anti-emetic action of Alizapride is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone (CTZ) in the central nervous system (CNS)ãthis action prevents nausea and vomiting triggered by most stimuli. Structurally similar to metoclopramide and, therefore, shares similar other atributres related to emesis and prokinetics.

Pharmacodynamics:

Alizapride is a dopamine antagonist.

IUPAC:
6-methoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-2H-1, 2, 3-benzotriazole-5-carboxamide
ATC:
A03FA05
PubChem:
43008
DrugBank:
DB01425
Formula:
C21H19N3O3S
Molecular Mass:
315.3702
Synonyms:
Alizaprida [inn-spanish] Alizapridum [inn-latin]
SMILES:
COC1=CC2=NNN=C2C=C1C(=O)NCC1CCCN1CC=C
InChi:
KSEYRUGYKHXGFW-UHFFFAOYSA-N
General Reference:
General Reference:

  1. Bleiberg H, Gerard B, Dalesio O, Crespeigne N, Rozencweig M: Activity of a new antiemetic agent: alizapride. A randomized double-blind crossover controlled trial. Cancer Chemother Pharmacol. 1988;22(4):316-20. Pubmed

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