Product Name

Alizapride

Name: Alizapride - LGM Pharma
SKU: 59338-93-1

CAS Number

59338-93-1

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Product Name:

Alizapride

CAS Number:

59338-93-1

Indication:

Alizapride is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.

Mode of Action:

The anti-emetic action of Alizapride is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone (CTZ) in the central nervous system (CNS)ãthis action prevents nausea and vomiting triggered by most stimuli. Structurally similar to metoclopramide and, therefore, shares similar other atributres related to emesis and prokinetics.

Pharmacodynamics:

Alizapride is a dopamine antagonist.

IUPAC:

6-methoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-2H-1, 2, 3-benzotriazole-5-carboxamide

ATC:

A03FA05

PubChem:

43008

DrugBank:

DB01425

Formula:

C₂₁H₁₉N₃O₃S

Molecular Mass:

315.3702

Synonyms:

Alizaprida [inn-spanish] Alizapridum [inn-latin]

SMILES:

COC1=CC2=NNN=C2C=C1C(=O)NCC1CCCN1CC=C

InChi:

KSEYRUGYKHXGFW-UHFFFAOYSA-N

General Reference:

Bleiberg H, Gerard B, Dalesio O, Crespeigne N, Rozencweig M: Activity of a new antiemetic agent: alizapride. A randomized double-blind crossover controlled trial. Cancer Chemother Pharmacol. 1988;22(4):316-20. Pubmed

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Alizapride

59338-93-1

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