Product Name

Afatinib Dimaleate

CAS Number

850140-73-7

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Product Name:
Afatinib Dimaleate
CAS Number:
850140-73-7
Indication:
Afatinib is a kinase inhibitor indicated for the first-line treatment of patient with metastatic non-small cell lung cancer (NSCLC) whose tumours have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test.
Mode of Action:

Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signalling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumour growth was inhibited.

Pharmacodynamics:

Afatinib did not effect the QTc interval.

Metabolism:

Enzymatic metabolism of afatinib is minimal. Covalent adducts to proteins are the major circulating metabolites.

Toxicity:

Most common adverse reactions (≥20%) are diarrhea, rash/dermatitis, acneiform, stomatitis, paronychia, dry skin, decreased appetite, pruritus.

IUPAC:
2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)- 6-quinazolinyl)-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:2)
ATC:
DB08916
PubChem:
10184653
DrugBank:
DB08916
Formula:
C24-H25-Cl-F-N5-O3.2(C4-H4-O4)
Molecular Mass:
718.0877
Synonyms:
2E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydrofuran-3-yl)oxy)quinazolin- 6-yl)-4-(dimethylamino)but-2-enamide bis(hydrogen (2Z)-but-2-enedioate), Afatinib dimaleate, BIBW 2992MA2, BIBW2992 MA2, Gilotrif, UNII-V1T5K7RZ0B
SMILES:
CN(C/C=C/C(=O)Nc1c(cc2ncnc(c2c1)Nc3cc(c(cc3)F)Cl)O[C@@H]4COCC4)C.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
AHFS Code:
10:00
InChi:
1S/C24H25ClFN5O3.2C4H4O4/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15;2*5-3(6)1-2-4(7)8/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29);2*1-2H,(H,5,6)(H,7,8)/b4-3+;2*2-1-/t16-;;/m0../s1
General Reference:
General Reference:

 

  1. FDA label

 

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