Product Name

Adalimumab

Name: Adalimumab - CAS# 331731-18-1 Availability - API Supplier - LGM Pharma
SKU: 331731-18-1

CAS Number

331731-18-1

LGM Pharma is an API distributor. LGM Pharma supplies APIs as per CGMP with DMF support, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, or pharmacies.

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Product Name:

Adalimumab

CAS Number:

331731-18-1

Indication:

For treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn’s disease.

Mode of Action:

Adalimumab binds to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface TNF expressing cells in vitro in the presence of complement.

Pharmacodynamics:

Used in the treatment of immune system mediated diseases, adalimumab binds specifically to TNF-alpha and blocks its general cytokine effects, thereby reducing TNF-induced inflammation and halting tissue destruction.

Metabolism:

Most likely removed by opsonization via the reticuloendothelial system.

IUPAC:

Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimer

ATC:

L04AB04

PubChem:

BTD00049

DrugBank:

DB00051

Formula:

C₆₄₂₈H₉₉₁₂N₁₆₉₄O₁₉₈₇

Molecular Mass:

144190.3

Synonyms:

Ig gamma-1 chain C region, Adalimumab, D2E7, HSDB 7851, Humira, Immunoglobulin G1, anti-(human tumor necrosis factor), (human monoclonal D2E7 heavy chain), disulfide with human, monoclonal D2E7 light chain, dimer. Molecular weight is, approximately 148,000 daltons, LU200134, Trudexa, UNII-FYS6T7F842

AHFS Code:

32:00.0

General Reference:

PDB sequence Link
Patent Information Link

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

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Adalimumab

331731-18-1

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