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Adalimumab

CAS No:
331731-18-1 Categories: , , , ,
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Product Details:

  • Product Name: Adalimumab
  • CAS #: 331731-18-1
  • Mode of Action:

    Adalimumab binds to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface TNF expressing cells in vitro in the presence of complement.

  • Pharmacodynamics:

    Used in the treatment of immune system mediated diseases, adalimumab binds specifically to TNF-alpha and blocks its general cytokine effects, thereby reducing TNF-induced inflammation and halting tissue destruction.

  • Metabolism:

    Most likely removed by opsonization via the reticuloendothelial system.

  • IUPAC: Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimer
  • ATC: L04AB04
  • PubChem: BTD00049
  • DrugBank: DB00051
  • Formula: C6428H9912N1694O1987
  • Molecular Mass: 144190.3
  • Synonyms: Ig gamma-1 chain C region, Adalimumab, D2E7, HSDB 7851, Humira, Immunoglobulin G1, anti-(human tumor necrosis factor), (human monoclonal D2E7 heavy chain), disulfide with human, monoclonal D2E7 light chain, dimer. Molecular weight is, approximately 148,000 daltons, LU200134, Trudexa, UNII-FYS6T7F842
  • AHFS Code: 32:00.0
  • General Reference:

     

    1. PDB sequence Link
    2. Patent Information Link
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