Product Name

Adalimumab

CAS Number

331731-18-1

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Product Name:
Adalimumab
CAS Number:
331731-18-1
Indication:
For treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn’s disease.
Mode of Action:

Adalimumab binds to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface TNF expressing cells in vitro in the presence of complement.

Pharmacodynamics:

Used in the treatment of immune system mediated diseases, adalimumab binds specifically to TNF-alpha and blocks its general cytokine effects, thereby reducing TNF-induced inflammation and halting tissue destruction.

Metabolism:

Most likely removed by opsonization via the reticuloendothelial system.

IUPAC:
Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimer
ATC:
L04AB04
PubChem:
BTD00049
DrugBank:
DB00051
Formula:
C6428H9912N1694O1987
Molecular Mass:
144190.3
Synonyms:
Ig gamma-1 chain C region, Adalimumab, D2E7, HSDB 7851, Humira, Immunoglobulin G1, anti-(human tumor necrosis factor), (human monoclonal D2E7 heavy chain), disulfide with human, monoclonal D2E7 light chain, dimer. Molecular weight is, approximately 148,000 daltons, LU200134, Trudexa, UNII-FYS6T7F842
AHFS Code:
32:00.0
General Reference:
General Reference:

 

  1. PDB sequence Link
  2. Patent Information Link

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Questions? Call our customer API support number 1-(800)-881-8210. 

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