Product Name

Adalimumab

Name: Adalimumab - CAS# 331731-18-1 Availability - API Supplier - LGM Pharma
SKU: 331731-18-1

CAS Number

331731-18-1

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Product Name:

Adalimumab

CAS Number:

331731-18-1

Indication:

For treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn’s disease.

Mode of Action:

Adalimumab binds to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface TNF expressing cells in vitro in the presence of complement.

Pharmacodynamics:

Used in the treatment of immune system mediated diseases, adalimumab binds specifically to TNF-alpha and blocks its general cytokine effects, thereby reducing TNF-induced inflammation and halting tissue destruction.

Metabolism:

Most likely removed by opsonization via the reticuloendothelial system.

IUPAC:

Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimer

ATC:

L04AB04

PubChem:

BTD00049

DrugBank:

DB00051

Formula:

C₆₄₂₈H₉₉₁₂N₁₆₉₄O₁₉₈₇

Molecular Mass:

144190.3

Synonyms:

Ig gamma-1 chain C region, Adalimumab, D2E7, HSDB 7851, Humira, Immunoglobulin G1, anti-(human tumor necrosis factor), (human monoclonal D2E7 heavy chain), disulfide with human, monoclonal D2E7 light chain, dimer. Molecular weight is, approximately 148,000 daltons, LU200134, Trudexa, UNII-FYS6T7F842

AHFS Code:

32:00.0

General Reference:

PDB sequence Link
Patent Information Link

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

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Adalimumab

331731-18-1

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