Product Name

Adalimumab

CAS Number

331731-18-1

LGM Pharma is an API distributor. LGM Pharma can supply CGMP and/or DMF products, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, pharmacies, or any pharmaceutical companies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:
Adalimumab
CAS Number:
331731-18-1
Indication:
For treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn’s disease.
Mode of Action:

Adalimumab binds to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface TNF expressing cells in vitro in the presence of complement.

Pharmacodynamics:

Used in the treatment of immune system mediated diseases, adalimumab binds specifically to TNF-alpha and blocks its general cytokine effects, thereby reducing TNF-induced inflammation and halting tissue destruction.

Metabolism:

Most likely removed by opsonization via the reticuloendothelial system.

IUPAC:
Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimer
ATC:
L04AB04
PubChem:
BTD00049
DrugBank:
DB00051
Formula:
C6428H9912N1694O1987
Molecular Mass:
144190.3
Synonyms:
Ig gamma-1 chain C region, Adalimumab, D2E7, HSDB 7851, Humira, Immunoglobulin G1, anti-(human tumor necrosis factor), (human monoclonal D2E7 heavy chain), disulfide with human, monoclonal D2E7 light chain, dimer. Molecular weight is, approximately 148,000 daltons, LU200134, Trudexa, UNII-FYS6T7F842
AHFS Code:
32:00.0
General Reference:
General Reference:

 

  1. PDB sequence Link
  2. Patent Information Link

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210. 

Ask us about this product

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants
  • Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any submission type based on specific customer requirements

Find an API Product

SEARCH
Generic filters