Product Name

Acyclovir

CAS Number

59277-89-3

LGM Pharma is an API distributor. LGM Pharma can supply CGMP and/or DMF products, subject to availability and manufacturer requirements. LGM Pharma does not sell or supply APIs or finished dosage products to individual patients, doctors, pharmacies, or any pharmaceutical companies.

Questions? Call our customer API support number 1-(800)-881-8210

Product Name:
Acyclovir
CAS Number:
59277-89-3
Indication:
For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox
Mode of Action:

Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts aciclovir to the aciclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Aciclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, aciclovir triphosphate inhibits DNA synthesis by acting as a chain terminator.

Pharmacodynamics:

Aciclovir (INN) or acyclovir (USAN, former BAN) is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of aciclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.

Metabolism:

Hepatic, the only major urinary metabolite that has been detected is 9-carboxymethoxymethylguanine.

Toxicity:

Aciclovir may cause nephrotoxicity (crystallization of aciclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of aciclovir therapy. However, there is no well-defined relationship between aciclovir concentrations in the blood and these adverse effects.

IUPAC:
6H-Purin-6-one, 1, 9-dihydro-2-amino-9-((2-hydroxyethoxy)methyl)-
ATC:
J05AB01 D06BB03 S01AD03
PubChem:
2022
DrugBank:
DB00787 (APRD00567, EXPT00406)
Formula:
C8H11N5O3
Molecular Mass:
225.21
Synonyms:
2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one, 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-, 9-((2-Hydroxyethoxy)methyl)guanine, ACV, Aciclovir, Aciclovirum, Aciclovirum [INN-Latin], Aciclovirum [Latin], Activir, Acycloguanosine, Acyclovir, BW-248U, CCRIS 1953, DRG-0008, EINECS 261-685-1, HSDB 6511, Hascovir, NSC 645011, UNII-X4HES1O11F, Vipral, Virorax, W-248-U, Wellcome-248U, Zovirax
SMILES:
c1nc2c(=O)[nH]c(nc2n1COCCO)N
InChi:
InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
General Reference:
General Reference:

O’Brien JJ, Campoli-Richards DM: Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1989 Mar;37(3):233-309. Pubmed

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

LGM currently offers Monoclonal Antibodies (mAbs) for non-GMP/R&D use. Please inquire about Monoclonal Antibodies produced under GMP conditions.

Questions? Call our customer API support number 1-(800)-881-8210. 

Ask us about this product

API’s From Quality Manufacturers:

  • Streamlined API supply towards initial research stages as well as larger quantities of cGMP material for clinical trials and product commercialization
  • Premium quality GMP certified and fully accredited API manufacturing plants
  • Technical packages as well as access to filed DMF, ASMF or CEP (subject to availability)
  • Regulatory and technical assistance towards any submission type based on specific customer requirements

Find an API Product

SEARCH
Generic filters