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Product Details:

  • Product Name: Abciximab
  • CAS #: 143653-53-6
  • Mode of Action:

    Abciximab binds to the intact platelet GPIIb/IIIa receptor, which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation. This binding is thought to involve steric hindrance and/or conformational alterations which block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GPIIb/IIIa.

  • Pharmacodynamics:

    Abciximab inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules to GPIIb/IIIa receptor sites on activated platelets. GPIIb/IIIa is the major surface receptor involved in the final pathway of platelet aggregation. Abciximab is thought to proclude GPIIb/IIIa substrate binding via steric hindrance and/or conformational effects rather than by direct interaction with the arginine-glycine-aspartic acid binding site of the receptor.

  • Metabolism:

    Most likely removed by opsonization via the reticuloendothelial system when bound to platelets, or by human antimurine antibody production. Excreted renally.

  • ATC: B01AC13
  • PubChem: BTD00041
  • DrugBank: DB00054 (BIOD00041, BTD00041)
  • Formula: C20H34O5
  • Molecular Mass: 145651.1
  • Synonyms: 7E3 antibody antiGPIIBIIIa c7E3 ReoPro
  • AHFS Code: 32:00.0
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