Featured Client in Action July 2019

InSitu Biologics has shifted management of their supply chain to LGM Pharma, including sourcing and logistics related to APIs and key materials used in production of their hydrogel Matrix™.

Featured Client In Action July 2019

InSitu Biologics has shifted management of their supply chain to LGM Pharma, including sourcing and logistics related to APIs and key materials used in production of their hydrogel Matrix™.

What We Do

anestagelInSitu Biologics develops and produces implantable time release products composed of its proprietary and tunable bio-polymeric hydrogel, Matrix™. Implantable, tunable compounds are gaining attention in biomedical applications targeting tissue and nerves, however, we are unaware of any that are truly similar to our three part, completely biocompatible, pH neutral Matrix product.

InSitu is pursuing applications with Matrix for both soft and bone tissues. Our ability to encapsulate compounds with our medical device and create biopolymers & mixtures used in regenerative applications and pain management for a wide and ever-growing range of treatments, from osteoarthritis to ophthalmic procedures, presents enormous partnering opportunities for InSitu.

Procured through an exclusive license agreement via our manufacturing and advance development partner, Matrix was invented and patented by Cleveland Clinic Foundation. InSitu has continued development of the platform, including cytotoxicity, genotoxity and multiple GLP animal studies in several indications supporting conceptual clinical applications.

Technology Platform

All of the components in InSitu’s Matrix™ (Tunable BioHydrogel) either occur naturally in the human body or easily can be metabolized by the body. Matrix is extremely hygroscopic, as most of the weight is water (>90% aqueous buffer). Our ability to accurately tune the physical form and rate of absorption to the targeted length of use for a specific tissue is highly desirable for the patient, physician and all members in the patient care continuum. We believe that the end result of Matrix being combined with the “caine” family of pharmaceuticals could result in extremely safe, biocompatible and highly effective products, while also reducing the chances of potential addiction to pain management therapeutics.

Our technology is protected by numerous issued, allowed or pending patents, and multiple trademarks. Patents are issued worldwide, including the EU, Japan, and the U.S.

 
 

What We Do

anestagelInSitu Biologics develops and produces implantable time release products composed of its proprietary and tunable bio-polymeric hydrogel, Matrix™. Implantable, tunable compounds are gaining attention in biomedical applications targeting tissue and nerves, however, we are unaware of any that are truly similar to our three part, completely biocompatible, pH neutral Matrix product.

InSitu is pursuing applications with Matrix for both soft and bone tissues. Our ability to encapsulate compounds with our medical device and create biopolymers & mixtures used in regenerative applications and pain management for a wide and ever-growing range of treatments, from osteoarthritis to ophthalmic procedures, presents enormous partnering opportunities for InSitu.

Procured through an exclusive license agreement via our manufacturing and advance development partner, Matrix was invented and patented by Cleveland Clinic Foundation. InSitu has continued development of the platform, including cytotoxicity, genotoxity and multiple GLP animal studies in several indications supporting conceptual clinical applications.

Technology Platform

All of the components in InSitu’s Matrix™ (Tunable BioHydrogel) either occur naturally in the human body or easily can be metabolized by the body. Matrix is extremely hygroscopic, as most of the weight is water (>90% aqueous buffer). Our ability to accurately tune the physical form and rate of absorption to the targeted length of use for a specific tissue is highly desirable for the patient, physician and all members in the patient care continuum. We believe that the end result of Matrix being combined with the “caine” family of pharmaceuticals could result in extremely safe, biocompatible and highly effective products, while also reducing the chances of potential addiction to pain management therapeutics.

Our technology is protected by numerous issued, allowed or pending patents, and multiple trademarks. Patents are issued worldwide, including the EU, Japan, and the U.S.

 
 

Overview

gel and diffusion

Our Sustained Release, Tunable BioHydrogel products for peri-operative use in People and Animal Health – AnestaGel and AniGel SR, respectively – possess physical properties that allow us to create less viscous products to coat surfaces for migration to small spaces, and to create more viscous products that prevent migration from surgical sites. We accomplish this enhanced drug delivery time and continuous drug elution by varying the substitution percentage to alter absorption rates. In every study we have performed, AniGel SR has eluted more pain-relieving medicine than Nocita, and we have proven the effectiveness of that drug delivery.

Overview

gel and diffusion

Our Sustained Release, Tunable BioHydrogel products for peri-operative use in People and Animal Health – AnestaGel and AniGel SR, respectively – possess physical properties that allow us to create less viscous products to coat surfaces for migration to small spaces, and to create more viscous products that prevent migration from surgical sites. We accomplish this enhanced drug delivery time and continuous drug elution by varying the substitution percentage to alter absorption rates. In every study we have performed, AniGel SR has eluted more pain-relieving medicine than Nocita, and we have proven the effectiveness of that drug delivery.

Product Opportunity

Examples of surgical procedures

Examples of surgical procedures

We believe that AniGel SR, composed of our Matrix Technology and our proprietary mix of bupivacaine, could be brought to the rapidly expanding $200B+ annual Worldwide Animal Health market in the very near future by the right commercial partner.

The combined surgical market for the three segments above represents over 50,000,000 surgeries annually, at a projected ASAP of $100 for Canine and Feline, and $275 for Equine.

In just two years, over 14,000 of the 104,000 veterinarians in the US have been trained on the use of Nocita, an analgesic extending liposome injection. AniGel has outperformed Nocita in head to head tests measuring pain relief and the level of non-toxic pain relief medicine in the bloodstream.

For more information on InSitu Biologics and their products, please visit their website at www.insitubiologics.com or contact our business development team at LGM for further details.

Product Opportunity

Examples of surgical procedures

We believe that AniGel SR, composed of our Matrix Technology and our proprietary mix of bupivacaine, could be brought to the rapidly expanding $200B+ annual Worldwide Animal Health market in the very near future by the right commercial partner.

The combined surgical market for the three segments above represents over 50,000,000 surgeries annually, at a projected ASAP of $100 for Canine and Feline, and $275 for Equine.

For more information on InSitu Biologics and their products, please visit their website at www.insitubiologics.com or contact our business development team at LGM for further details.

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