57-22-7 Category:
  • #LGM Pharma is a Vincristine CAS# 57-22-7 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 57-22-7
  • AHFC code: 10:00.0
  • Synonyms: 22-Oxovincaleukoblastine Indole alkaloid LCR Leurocristine VCR VIN Vincristina [DCIT] Vincristine Sulfate Vincristinum [INN-Latin] Vincrstine Vincrystine Z-D-Val-Lys(Z)-OH
  • ATC Code: L01CA02
  • Chemical Formula: C45H54N4O8
  • Molecular Weight: 824.9576
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00541 (APRD00495)
  • SMILES: CC[C,]1(O)C[C,H]2CN(C1)CCC1=C(NC3=CC=CC=C13)[C,,](C2)(C(=O)OC)C1=C(OC)C=C2N(C=O)[C,,H]3[C,]4(CCN5CC=C[C,](CC)([C,,H]45)[C,,H](OC(C)=O)[C,]3(O)C(=O)OC)C2=C1
  • PubChem: 5978
  • IUPAC:

Additional Details

For treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, acute panmyelosis
Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Mode of Action:
The antitumor activity of Vincristine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Vincristine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca2+-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.
IVN-RAT LD50 1300 mg/kg; IPR-MUS LD50 5.2 mg/kg
General Reference:
Graf WD, Chance PF, Lensch MW, Eng LJ, Lipe HP, Bird TD: Severe vincristine neuropathy in Charcot-Marie-Tooth disease type 1A. Cancer. 1996 Apr 1;77(7):1356-62. Pubmed Qweider M, Gilsbach JM, Rohde V: Inadvertent intrathecal vincristine administration: a neurosurgical emergency. Case report. J Neurosurg Spine. 2007 Mar;6(3):280-3. Pubmed JOHNSON IS, ARMSTRONG JG, GORMAN M, BURNETT JP Jr: THE VINCA ALKALOIDS: A NEW CLASS OF ONCOLYTIC AGENTS. Cancer Res. 1963 Sep;23:1390-427. Pubmed
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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