Tropicamide

CAS No:
1508-75-4 Category:
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Product Details:

  • CAS No: 1508-75-4
  • AHFC code: 52:24.0
  • Synonyms:
  • ATC Code: S01FA06
  • Chemical Formula: C8H16O2
  • Molecular Weight: 284.3529
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00809 (APRD00287)
  • SMILES: CCN(CC1=CC=NC=C1)C(=O)C(CO)C1=CC=CC=C1
  • InChl: BGDKAVGWHJFAGW-UHFFFAOYSA-N
  • PubChem: 5593
  • IUPAC: N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide

Additional Details

Indication:
Indicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye.
Pharmacodynamics:
Tropicamide belongs to the group of medicines called anti-muscarinics. Tropicamide blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved controlling the pupil size and the shape of the lens. By blocking these receptors, tropicamide produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia). Tropicamide is given as eye drops to dilate the pupil and relax the lens so that eye examinations can be carried out thoroughly.
Mode of Action:
Tropicamide binds to and blocks the receptors in the muscles of the eye (muscarinic receptor M4). Tropicamide acts by blocking the responses of the iris sphincter muscle to the iris and ciliary muscles to cholinergic stimulation, producing dilation of the pupil and paralysis of the ciliary muscle.
Metabolism:
Toxicity:
Overdose can casue dry mouth, blurred vision, photophobia, hallucinations and rapid/irregular pulse.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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