127-48-0 Category:
  • #LGM Pharma is a Trimethadione CAS# 127-48-0 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 127-48-0
  • AHFC code:
  • Synonyms: Trimetadione Trimethadion Trimethdione
  • ATC Code: N03AC02
  • Chemical Formula: C19H23N5O3
  • Molecular Weight: 143.1406
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00347 (APRD00315)
  • SMILES: CN1C(=O)OC(C)(C)C1=O
  • PubChem: 5576
  • IUPAC: trimethyl-1,3-oxazolidine-2,4-dione

Additional Details

Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications.
Paramethadione and trimethadione are anticonvulsants indicated in the control of absence (petit mal) seizures that are refractory to treatment with other medications. Dione anticonvulsants are used in the treatment of epilepsy. They act on the central nervous system (CNS) to reduce the number of seizures.
Mode of Action:
Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.
Symptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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