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LGM Pharma offers this active ingredient but not the finished dosage forms.
CAS No: 127-48-0
Synonyms: Trimetadione Trimethadion Trimethdione
ATC Code: N03AC02
Chemical Formula: C19H23N5O3
Molecular Weight: 143.1406
Assay/Purity: Typically NLT 98%
DrugBank: DB00347 (APRD00315)
Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications.
Paramethadione and trimethadione are anticonvulsants indicated in the control of absence (petit mal) seizures that are refractory to treatment with other medications. Dione anticonvulsants are used in the treatment of epilepsy. They act on the central nervous system (CNS) to reduce the number of seizures.
Mode of Action:
Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.
Symptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision.
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