• #LGM Pharma is a Triamcinolone CAS# 124-94-7 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 124-94-7
  • AHFC code: 52:08.08 84:06.00 68:04.00
  • Synonyms: Fluoxiprednisolone Fluoxyprednisolone Tiamcinolonum [INN-Latin] Triamcinalone Triamcinolona [INN-Spanish] Triamcinolone acetonide Triamcinolone diacetate Triamcinolone hexacetonide Triamcinolonum [INN]
  • ATC Code: A01AC01 D07AB09 D07XB02 H02AB08 R01AD11 R03BA06 S01BA05 C05AA12
  • Chemical Formula: C8H8Cl3N3O4S2
  • Molecular Weight: 394.4339
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00620 (APRD00422)
  • SMILES: C[C,]12C[C,H](O)[C,,]3(F)[C,,H](CCC4=CC(=O)C=C[C,]34C)[C,,H]1C[C,,H](O)[C,]2(O)C(=O)CO
  • InChl: GFNANZIMVAIWHM-OBYCQNJPSA-N
  • PubChem: 31307
  • IUPAC: (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one

Additional Details

Indication:
For the treatment of perennial and seasonal allergic rhinitis.
Pharmacodynamics:
Triamcinolone and its derivatives are synthetic glucocorticoids that are used for their antiinflammatory or immunosuppressive properties.
Mode of Action:
The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Firstly, however, these glucocorticoids bind to the glucocorticoid receptors which translocate into the nucleus and bind DNA (GRE) and change genetic expression both positively and negatively. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
Metabolism:
Hepatic.
Toxicity:
LD50=>500mg/kg (in rats)
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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