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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 2398-96-1
  • AHFC code: 84:04.08.40
  • Synonyms:
  • ATC Code: D01AE18
  • Chemical Formula: C22H31NO
  • Molecular Weight: 307.409
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00525 (APRD01607)
  • SMILES: CN(C(=S)OC1=CC2=CC=CC=C2C=C1)C1=CC=CC(C)=C1
  • InChl: FUSNMLFNXJSCDI-UHFFFAOYSA-N
  • PubChem: 5510
  • IUPAC: N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide

Additional Details

Indication:
Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.
Pharmacodynamics:
Tolnaftate is a synthetic over-the-counter anti-fungal agent.
Mode of Action:
Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.
Metabolism:
Toxicity:
Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
General Reference:
Barrett-Bee K, Dixon G: Ergosterol biosynthesis inhibition: a target for antifungal agents. Acta Biochim Pol. 1995;42(4):465-79. Pubmed Ryder NS, Frank I, Dupont MC: Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60. Pubmed
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