• #LGM Pharma is a Tobramycin CAS# 32986-56-4 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 32986-56-4
  • AHFC code: 52:04.04 08:12.02
  • Synonyms: 3'-Deoxykanamycin B SPRC-AB01 tobramycin solution for inhalation Tobramycin Sulfate
  • ATC Code: J01GB01 S01AA12
  • Chemical Formula: C14H21N3O3S
  • Molecular Weight: 467.5145
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00684 (APRD00582)
  • SMILES: NC[C,H]1O[C,H](O[C,,H]2[C,,H](N)C[C,,H](N)[C,H](O[C,H]3O[C,H](CO)[C,,H](O)[C,H](N)[C,H]3O)[C,H]2O)[C,H](N)C[C,,H]1O
  • PubChem: 5496
  • IUPAC: (2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol

Additional Details

For the treatment of pseudomonas aeruginosa lung infections. Also being investigated for use in the treatment of sinus infections.
Tobramycin, an aminoglycoside antibiotic obtained from cultures of Streptomyces tenebrarius, is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, bacteremia and sepsis, respiratory infections including those associated with cystic fibrosis, osteomyelitis, and diabetic foot and other soft-tissue infections. It acts primarily by disrupting protein synthesis, leading to altered cell membrane permeability, progressive disruption of the cell envelope, and eventual cell death. Tobramycin has in vitro activity against a wide range of gram-negative organisms including Pseudomonas aeruginosa.
Mode of Action:
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.
LD50=441mg/kg (s.c. in mice)
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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